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Table 4 Minimum inhibitory concentration of carbapenems of 5 carbapenems-resistant E. aerogenes and 5 carbapenems-resistant E. cloacae isolates by agar dilution with or without efflux inhibitor CCCP

From: Clonality, outer-membrane proteins profile and efflux pump in KPC- producing Enterobacter sp. in Brazil

Antimicrobial agent

E. aerogenes (non-harboring acrART gene)

N = 5

E. cloacae (harboring acrART gene)

N = 5

 
 

50 mg/mL CCCP

100 mg/mL CCCP

 
 

MIC (mg/mL) SD

MIC (mg/mL)

SD

Imipenem

8

8

32

64

2

25,75

4

8

4

8

32

11,79

Imipenem + CCCP

≤0,125

≤0,125

≤0,125

≤0,125

0,25

0

≤0,125

≤0,125

≤0,125

≤0,125

≤0,125

0

Meropenem

4

4

8

32

8

11,79

4

4

2

8

16

5,58

Meropenem + CCCP

≤0,125

≤0,125

1

≤0,125

1

0

≤0,125

≤0,125

≤0,125

≤0,125

≤0,125

0

Ertapenem

32

64

32

256

32

93,38

16

16

8

32

32

10,73

Ertapenem + CCCP

≤0,125

2

≤0,125

2

4

1,61

8

8

≤0,125

≤0,125

≤0,125

4,35

  1. All isolates harbored KPC
  2. SD standart deviation