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Table 4 Minimum inhibitory concentration of carbapenems of 5 carbapenems-resistant E. aerogenes and 5 carbapenems-resistant E. cloacae isolates by agar dilution with or without efflux inhibitor CCCP

From: Clonality, outer-membrane proteins profile and efflux pump in KPC- producing Enterobacter sp. in Brazil

Antimicrobial agent E. aerogenes (non-harboring acrART gene)
N = 5
E. cloacae (harboring acrART gene)
N = 5
 
  50 mg/mL CCCP 100 mg/mL CCCP  
  MIC (mg/mL) SD MIC (mg/mL) SD
Imipenem 8 8 32 64 2 25,75 4 8 4 8 32 11,79
Imipenem + CCCP ≤0,125 ≤0,125 ≤0,125 ≤0,125 0,25 0 ≤0,125 ≤0,125 ≤0,125 ≤0,125 ≤0,125 0
Meropenem 4 4 8 32 8 11,79 4 4 2 8 16 5,58
Meropenem + CCCP ≤0,125 ≤0,125 1 ≤0,125 1 0 ≤0,125 ≤0,125 ≤0,125 ≤0,125 ≤0,125 0
Ertapenem 32 64 32 256 32 93,38 16 16 8 32 32 10,73
Ertapenem + CCCP ≤0,125 2 ≤0,125 2 4 1,61 8 8 ≤0,125 ≤0,125 ≤0,125 4,35
  1. All isolates harbored KPC
  2. SD standart deviation