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Table 2 Proteins differentially produced among the recovered and control condition

From: A shift in the virulence potential of Corynebacterium pseudotuberculosis biovar ovis after passage in a murine host demonstrated through comparative proteomics

Accession

Description

Score

Fold Change_Log(2) a

SecretomeP

 Transport

  D9Q5H9_CORP1

Periplasmic binding protein LacI

5601,78

3,26

0.612642

  D9Q6G4_CORP1

Oligopeptide binding protein oppAb

4120,1

3,00

0.892226

  D9Q4T5_CORP1

ABC transporter domain containing ATP

1264,05

2,57

0.084974

  D9Q7K5_CORP1

Oligopeptide binding protein oppAb

33697,17

2,11

0.873687

  D9Q5B8_CORP1

Oligopeptide binding protein oppAb

852,88

1,88

0.849217

  D9Q6C3_CORP1

ABC type metal ion transport system permease

650,43

1,59

0.078043

  D9Q796_CORP1

Glutamate binding protein GluB

6254,68

−1,46

0.840325

  D9Q7W9_CORP1

Iron(3+)-hydroxamate-binding protein fhuD

2774,62

−1,62

0.824030

 Cell division

  D9Q7G1_CORP1

Septum formation initiator protein

2071,46

1,38

0.551153

 Cell adhesion

  D9Q5H7_CORP1

Hypothetical protein

115906,3

1,51

0.840443

 DNA synthesis and repair

  D9Q7J1_CORP1

GTP binding protein YchF

3487,98

2,68

0.042575

  D9Q5F7_CORP1

Chromosome partitioning protein ParBb

2467,24

2,44

0.052395

  D9Q5G6_CORP1

DNA polymerase III subunit beta

1907,74

1,80

0.071008

  D9Q5V6_CORP1

Nucleoid associated proteinc

68097,59

1,59

0.070074

 Transcription

  D9Q6J8_CORP1

DNA directed RNA polymerase subunit

29671,46

1,38

0.094910

  D9Q748_CORP1

tRNA rRNA methyltransferase

2467,24

1,27

0.060356

  D9Q8L3_CORP1

DNA directed RNA polymerase subunit omega

3784,13

−1,21

0.700214

  D9Q6D1_CORP1

DNA directed RNA polymerase subunit beta

2611,89

−1,27

0.067182

  D9Q8A5_CORP1

RNA polymerase-binding protein RbpA

10787,51

−1,75

0.103548

 Translation

  D9Q584_CORP1

30S ribosomal protein S6

20750,74

4,82

0.047667

  D9Q6E4_CORP1

Elongation factor Gb

16882,71

3,25

0.082321

  D9Q5I3_CORP1

Peptidyl prolyl cis trans isomeraseb

61648,39

2,91

0.142641

  D9Q835_CORP1

Phenylalanine tRNA ligase beta subunit

1269,7

2,74

0.064869

  D9Q6L0_CORP1

50S ribosomal protein L13

5689,37

2,64

0.101816

  D9Q6H2_CORP1

50S ribosomal protein L5b

3269,32

2,12

0.076250

  D9Q918_CORP1

Proline tRNA ligaseb

932,79

2,12

0.072151

  D9Q6C0_CORP1

50S ribosomal protein L10b

27143,51

1,86

0.031374

  D9Q6F6_CORP1

50S ribosomal protein L23b

6947,79

1,85

0.060878

  D9Q6H1_CORP1

50S ribosomal protein L24

27887,33

1,75

0.078408

  F9Y2W9_CORP1

Hypothetical protein

3152,39

1,75

0.591013

  D9Q6H6_CORP1

30S ribosomal protein S8c,b

4941,19

1,56

0.088407

  D9Q6F3_CORP1

30S ribosomal protein S10b

25117,55

1,54

0.048124

  D9Q6G2_CORP1

50S ribosomal protein L29

2467,24

1,44

0.050948

  D9Q401_CORP1

50S ribosomal protein L27b

2467,24

1,38

0.081399

  D9Q7E8_CORP1

50S ribosomal protein L25

1358,05

−1,28

0.037225

  D9Q6H8_CORP1

50S ribosomal protein L18

8920,94

−1,31

0.049024

  D9Q7S4_CORP1

Homoserine dehydrogenase

698,17

−1,40

0.035138

  D9Q6B7_CORP1

50S ribosomal protein L1

10218.08

−1,63

0.633387

  D9Q4T4_CORP1

ATP dependent chaperone protein ClpB

1883,16

−1,80

0.045308

  D9Q8N9_CORP1

Aspartate tRNA ligase

1004,33

−2,18

0.092415

  D9Q7S2_CORP1

Arginine tRNA ligase

2679,11

−2,44

0.051908

 Pathogenesis

  D9Q8M7_CORP1

Metallopeptidase family M24

3213,83

5,55

0.050024

  D9Q608_CORP1

Penicillin binding protein transpeptidaseb

1215,32

3,68

0.859830

  D9Q827_CORP1

Metallo beta lactamase superfamily proteinc

629,38

2,64

0.144158

  D9Q721_CORP1

Hypothetical proteinc

112025

2,24

0.260801

  D9Q7K8_CORP1

Trypsin like serine protease

35041,27

1,96

0.648370

  D9Q416_CORP1

ATP dependent Clp protease proteolyticb

2467,24

1,77

0.087255

  D9Q639_CORP1

Secreted hydrolaseb

22798,13

1,75

0.072385

  D9Q588_CORP1

Penicillin binding proteinb

9951,61

1,26

0.916125

 Energy metabolism

  D9Q787_CORP1

Glucose-6-phosphate isomerase

1025,89

4,50

0.058841

  D9Q7G0_CORP1

Enolaseb

53290,95

2,18

0.068928

  D9Q651_CORP1

Succinate dehydrogenase flavoprotein

797,48

2,02

0.159059

  D9Q4P2_CORP1

Acetate kinaseb

10828,79

1,96

0.063340

  D9Q8G5_CORP1

Aconitate hydrataseb

4250,81

1,85

0.217637

  D9Q4Z7_CORP1

Phosphoenolpyruvate carboxykinase GTPb

8764,35

1,66

0.147167

  D9Q7X0_CORP1

6 phosphofructokinase

1806,65

1,60

0.052885

  D9Q648_CORP1

Dihydrolipoyl dehydrogenase

4110,08

1,57

0.047180

  D9Q7T8_CORP1

ATP synthase subunit alpha

2467,24

1,49

0.070875

  D9Q752_CORP1

Citrate synthase

6299,21

−1,21

0.116042

  D9Q895_CORP1

6-Phosphogluconate dehydrogenase

4246,26

−1,89

0.050906

 Lipid metabolism

  D9Q520_CORP1

Glycerophosphoryl diester phosphodiestec

2494,25

4,03

0.802154

  D9Q718_CORP1

Methylmalonyl CoA carboxyltransferase 1b

2467,24

2,16

0.049504

 Amino acid metabolism

  D9Q5X8_CORP1

Aspartokinaseb

1944,81

2,86

0.043575

  D9Q4C2_CORP1

Succinyl CoA Coenzyme A transferase

10894,63

1,63

0.061344

  D9Q3L8_CORP1

Glutamine synthetase

320,71

−1,23

0.263700

  D9Q8H7_CORP1

Cysteine desulfurase

1689,36

−1,70

0.067087

 Stress response

  D9Q929_CORP1

Mycothione glutathione reductase

490,36

2,67

0.085017

  D9Q5T5_CORP1

Glyoxalase Bleomycin resistance proteinc

8420,32

2,21

0.226764

  D9Q424_CORP1

DSBA oxidoreductase

12179,8

2,09

0.061566

  D9Q566_CORP1

Universal stress protein Ab

2498,69

1,70

0.034684

  D9Q4P4_CORP1

Ferredoxin ferredoxin NADP reductaseb

1086,71

1,69

0.083585

  D9Q824_CORP1

Stress related proteinb

2467,24

1,54

0.035291

  D9Q692_CORP1

Thiol disulfide isomerase thioredoxin

3721,88

−2,25

0.438415

 Metabolism of nucleotides and nucleic acids

  D9Q4Y6_CORP1

Deoxycytidine triphosphate deaminase

887,26

2,39

0.216897

  D9Q6J1_CORP1

Adenylate kinase

15629,86

2,21

0.059568

  D9Q8L4_CORP1

Guanylate kinase

2467,24

1,34

0.050095

  D9Q6T2_CORP1

Ribokinase

890,09

−1,23

0.032324

  D9Q4E9_CORP1

Adenylosuccinate lyase

1441,99

−1,54

0.035597

  D9Q6P0_CORP1

D methionine binding lipoprotein metQ

11519,67

−1,93

0.817217

 Carbohydrate metabolism

  D9Q8V2_CORP1

UDP glucose 4 epimeraseb

2001,76

3,13

0.094403

  D9Q6V6_CORP1

Phosphomannomutase ManB

1730,63

2,05

0.053146

  D9Q659_CORP1

Formate acetyltransferase

5456,95

1,54

0.539548

  D9Q423_CORP1

Ribose-5-phosphate isomerase B

2467,24

1,38

0.064467

  D9Q6V1_CORP1

Mannose-1-phosphate guanylyltransferase

1612,45

−1,21

0.068085

 Nitrogen metabolism

  D9Q4Q8_CORP1

Cytochrome c nitrate reductase small

1118,33

2,68

0.901856

 Unknow function

  D9Q6T0_CORP1

Hypothetical protein

2277,6

3,62

0.050552

  D9Q4R2_CORP1

Hypothetical protein

442,07

3,35

0.866986

  D9Q6N1_CORP1

Hypothetical protein

561,84

3,02

0.062141

  D9Q8Q4_CORP1

Hypothetical proteinc

72711,5

2,96

0.974016

  D9Q832_CORP1

Hypothetical protein

1774,59

2,90

0.752478

  D9Q3S8_CORP1

Hypothetical proteind

837,6

2,78

0.231421

  D9Q7M9_CORP1

Hypothetical protein

3246,28

2,60

0.147602

  D9Q7I6_CORP1

Hypothetical protein

3751,96

2,42

0.707595

  D9Q739_CORP1

Hypothetical protein

2845,77

2,28

0.836229

  D9Q4C5_CORP1

Hypothetical protein

1339,3

1,83

0.023133

  D9Q5C3_CORP1

Hypothetical protein

111234,6

1,49

0.946918

  D9Q700_CORP1

Hypothetical protein

2467,24

1,49

0.072810

  D9Q657_CORP1

Hypothetical protein

1172,66

1,41

0.830926

  D9Q6F2_CORP1

Hypothetical protein

2467,24

1,34

0.061860

  D9Q7X5_CORP1

Hypothetical protein

38716,45

−1,21

0.825761

  D9Q4T9_CORP1

Hypothetical protein

553,76

−1,28

0.934591

  D9Q6R6_CORP1

Hypothetical protein

1457,62

−1,40

0.206908

  D9Q890_CORP1

Hypothetical protein

1948,52

−1,51

0.847549

  D9Q6M6_CORP1

Hypothetical proteinc

1935,68

−1,90

0.823541

 Others

  D9Q6I3_CORP1

Maltotriose binding protein

5210,9

5,22

0.864851

  D9Q4A3_CORP1

DsbG protein

3101,13

2,06

0.814366

  D9Q6N9_CORP1

D methionine binding lipoprotein metQ

2665,58

1,79

0.764416

  D9Q732_CORP1

Carbonic anhydraseb

689,15

1,66

0.130559

  D9Q6W6_CORP1

Lipoprotein LpqB

1484,31

1,63

0.670057

  D9Q556_CORP1

LSR2 like protein

2714,21

1,49

0.096802

  D9Q5Q0_CORP1

UPF0145 protein

2467,24

1,37

0.025009

  D9Q7W0_CORP1

Hypothetical protein

2467,24

1,26

0.039678

  D9Q701_CORP1

UPF0182 protein

1682,98

1,26

0.869411

  D9Q8A3_CORP1

Protein yceIb

16885,01

1,21

0.901679

  D9Q5X4_CORP1

Serine aspartate repeat containing protein

528,36

−1,82

0.892317

  D9Q826_CORP1

DoxX family protein

697,26

−2,08

0.614317

  D9Q7W3_CORP1

Mycothiol acetyltransferase

947,33

−2,11

0.214833

  D9Q407_CORP1

Ornithine cyclodeaminase

2566,18

−2,58

0.048247

  1. aFold change - Ratio values to: 1002Rc:11002Ct_Log(2)Ratio ≥ 1.2 proteins with p < 0.05
  2. bIdentified in an isolated of C. pseudotuberculosis from ovine lymph nodes [Rees et al. [12]
  3. cInduced in 1002_ovis during to stress nitrosative [Pacheco et al. [57], Silva et al. [58]
  4. dPredicted LPXTG cell wall-anchoring motif