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Table 2 Proteins differentially produced among the recovered and control condition

From: A shift in the virulence potential of Corynebacterium pseudotuberculosis biovar ovis after passage in a murine host demonstrated through comparative proteomics

Accession Description Score Fold Change_Log(2) a SecretomeP
 Transport
  D9Q5H9_CORP1 Periplasmic binding protein LacI 5601,78 3,26 0.612642
  D9Q6G4_CORP1 Oligopeptide binding protein oppAb 4120,1 3,00 0.892226
  D9Q4T5_CORP1 ABC transporter domain containing ATP 1264,05 2,57 0.084974
  D9Q7K5_CORP1 Oligopeptide binding protein oppAb 33697,17 2,11 0.873687
  D9Q5B8_CORP1 Oligopeptide binding protein oppAb 852,88 1,88 0.849217
  D9Q6C3_CORP1 ABC type metal ion transport system permease 650,43 1,59 0.078043
  D9Q796_CORP1 Glutamate binding protein GluB 6254,68 −1,46 0.840325
  D9Q7W9_CORP1 Iron(3+)-hydroxamate-binding protein fhuD 2774,62 −1,62 0.824030
 Cell division
  D9Q7G1_CORP1 Septum formation initiator protein 2071,46 1,38 0.551153
 Cell adhesion
  D9Q5H7_CORP1 Hypothetical protein 115906,3 1,51 0.840443
 DNA synthesis and repair
  D9Q7J1_CORP1 GTP binding protein YchF 3487,98 2,68 0.042575
  D9Q5F7_CORP1 Chromosome partitioning protein ParBb 2467,24 2,44 0.052395
  D9Q5G6_CORP1 DNA polymerase III subunit beta 1907,74 1,80 0.071008
  D9Q5V6_CORP1 Nucleoid associated proteinc 68097,59 1,59 0.070074
 Transcription
  D9Q6J8_CORP1 DNA directed RNA polymerase subunit 29671,46 1,38 0.094910
  D9Q748_CORP1 tRNA rRNA methyltransferase 2467,24 1,27 0.060356
  D9Q8L3_CORP1 DNA directed RNA polymerase subunit omega 3784,13 −1,21 0.700214
  D9Q6D1_CORP1 DNA directed RNA polymerase subunit beta 2611,89 −1,27 0.067182
  D9Q8A5_CORP1 RNA polymerase-binding protein RbpA 10787,51 −1,75 0.103548
 Translation
  D9Q584_CORP1 30S ribosomal protein S6 20750,74 4,82 0.047667
  D9Q6E4_CORP1 Elongation factor Gb 16882,71 3,25 0.082321
  D9Q5I3_CORP1 Peptidyl prolyl cis trans isomeraseb 61648,39 2,91 0.142641
  D9Q835_CORP1 Phenylalanine tRNA ligase beta subunit 1269,7 2,74 0.064869
  D9Q6L0_CORP1 50S ribosomal protein L13 5689,37 2,64 0.101816
  D9Q6H2_CORP1 50S ribosomal protein L5b 3269,32 2,12 0.076250
  D9Q918_CORP1 Proline tRNA ligaseb 932,79 2,12 0.072151
  D9Q6C0_CORP1 50S ribosomal protein L10b 27143,51 1,86 0.031374
  D9Q6F6_CORP1 50S ribosomal protein L23b 6947,79 1,85 0.060878
  D9Q6H1_CORP1 50S ribosomal protein L24 27887,33 1,75 0.078408
  F9Y2W9_CORP1 Hypothetical protein 3152,39 1,75 0.591013
  D9Q6H6_CORP1 30S ribosomal protein S8c,b 4941,19 1,56 0.088407
  D9Q6F3_CORP1 30S ribosomal protein S10b 25117,55 1,54 0.048124
  D9Q6G2_CORP1 50S ribosomal protein L29 2467,24 1,44 0.050948
  D9Q401_CORP1 50S ribosomal protein L27b 2467,24 1,38 0.081399
  D9Q7E8_CORP1 50S ribosomal protein L25 1358,05 −1,28 0.037225
  D9Q6H8_CORP1 50S ribosomal protein L18 8920,94 −1,31 0.049024
  D9Q7S4_CORP1 Homoserine dehydrogenase 698,17 −1,40 0.035138
  D9Q6B7_CORP1 50S ribosomal protein L1 10218.08 −1,63 0.633387
  D9Q4T4_CORP1 ATP dependent chaperone protein ClpB 1883,16 −1,80 0.045308
  D9Q8N9_CORP1 Aspartate tRNA ligase 1004,33 −2,18 0.092415
  D9Q7S2_CORP1 Arginine tRNA ligase 2679,11 −2,44 0.051908
 Pathogenesis
  D9Q8M7_CORP1 Metallopeptidase family M24 3213,83 5,55 0.050024
  D9Q608_CORP1 Penicillin binding protein transpeptidaseb 1215,32 3,68 0.859830
  D9Q827_CORP1 Metallo beta lactamase superfamily proteinc 629,38 2,64 0.144158
  D9Q721_CORP1 Hypothetical proteinc 112025 2,24 0.260801
  D9Q7K8_CORP1 Trypsin like serine protease 35041,27 1,96 0.648370
  D9Q416_CORP1 ATP dependent Clp protease proteolyticb 2467,24 1,77 0.087255
  D9Q639_CORP1 Secreted hydrolaseb 22798,13 1,75 0.072385
  D9Q588_CORP1 Penicillin binding proteinb 9951,61 1,26 0.916125
 Energy metabolism
  D9Q787_CORP1 Glucose-6-phosphate isomerase 1025,89 4,50 0.058841
  D9Q7G0_CORP1 Enolaseb 53290,95 2,18 0.068928
  D9Q651_CORP1 Succinate dehydrogenase flavoprotein 797,48 2,02 0.159059
  D9Q4P2_CORP1 Acetate kinaseb 10828,79 1,96 0.063340
  D9Q8G5_CORP1 Aconitate hydrataseb 4250,81 1,85 0.217637
  D9Q4Z7_CORP1 Phosphoenolpyruvate carboxykinase GTPb 8764,35 1,66 0.147167
  D9Q7X0_CORP1 6 phosphofructokinase 1806,65 1,60 0.052885
  D9Q648_CORP1 Dihydrolipoyl dehydrogenase 4110,08 1,57 0.047180
  D9Q7T8_CORP1 ATP synthase subunit alpha 2467,24 1,49 0.070875
  D9Q752_CORP1 Citrate synthase 6299,21 −1,21 0.116042
  D9Q895_CORP1 6-Phosphogluconate dehydrogenase 4246,26 −1,89 0.050906
 Lipid metabolism
  D9Q520_CORP1 Glycerophosphoryl diester phosphodiestec 2494,25 4,03 0.802154
  D9Q718_CORP1 Methylmalonyl CoA carboxyltransferase 1b 2467,24 2,16 0.049504
 Amino acid metabolism
  D9Q5X8_CORP1 Aspartokinaseb 1944,81 2,86 0.043575
  D9Q4C2_CORP1 Succinyl CoA Coenzyme A transferase 10894,63 1,63 0.061344
  D9Q3L8_CORP1 Glutamine synthetase 320,71 −1,23 0.263700
  D9Q8H7_CORP1 Cysteine desulfurase 1689,36 −1,70 0.067087
 Stress response
  D9Q929_CORP1 Mycothione glutathione reductase 490,36 2,67 0.085017
  D9Q5T5_CORP1 Glyoxalase Bleomycin resistance proteinc 8420,32 2,21 0.226764
  D9Q424_CORP1 DSBA oxidoreductase 12179,8 2,09 0.061566
  D9Q566_CORP1 Universal stress protein Ab 2498,69 1,70 0.034684
  D9Q4P4_CORP1 Ferredoxin ferredoxin NADP reductaseb 1086,71 1,69 0.083585
  D9Q824_CORP1 Stress related proteinb 2467,24 1,54 0.035291
  D9Q692_CORP1 Thiol disulfide isomerase thioredoxin 3721,88 −2,25 0.438415
 Metabolism of nucleotides and nucleic acids
  D9Q4Y6_CORP1 Deoxycytidine triphosphate deaminase 887,26 2,39 0.216897
  D9Q6J1_CORP1 Adenylate kinase 15629,86 2,21 0.059568
  D9Q8L4_CORP1 Guanylate kinase 2467,24 1,34 0.050095
  D9Q6T2_CORP1 Ribokinase 890,09 −1,23 0.032324
  D9Q4E9_CORP1 Adenylosuccinate lyase 1441,99 −1,54 0.035597
  D9Q6P0_CORP1 D methionine binding lipoprotein metQ 11519,67 −1,93 0.817217
 Carbohydrate metabolism
  D9Q8V2_CORP1 UDP glucose 4 epimeraseb 2001,76 3,13 0.094403
  D9Q6V6_CORP1 Phosphomannomutase ManB 1730,63 2,05 0.053146
  D9Q659_CORP1 Formate acetyltransferase 5456,95 1,54 0.539548
  D9Q423_CORP1 Ribose-5-phosphate isomerase B 2467,24 1,38 0.064467
  D9Q6V1_CORP1 Mannose-1-phosphate guanylyltransferase 1612,45 −1,21 0.068085
 Nitrogen metabolism
  D9Q4Q8_CORP1 Cytochrome c nitrate reductase small 1118,33 2,68 0.901856
 Unknow function
  D9Q6T0_CORP1 Hypothetical protein 2277,6 3,62 0.050552
  D9Q4R2_CORP1 Hypothetical protein 442,07 3,35 0.866986
  D9Q6N1_CORP1 Hypothetical protein 561,84 3,02 0.062141
  D9Q8Q4_CORP1 Hypothetical proteinc 72711,5 2,96 0.974016
  D9Q832_CORP1 Hypothetical protein 1774,59 2,90 0.752478
  D9Q3S8_CORP1 Hypothetical proteind 837,6 2,78 0.231421
  D9Q7M9_CORP1 Hypothetical protein 3246,28 2,60 0.147602
  D9Q7I6_CORP1 Hypothetical protein 3751,96 2,42 0.707595
  D9Q739_CORP1 Hypothetical protein 2845,77 2,28 0.836229
  D9Q4C5_CORP1 Hypothetical protein 1339,3 1,83 0.023133
  D9Q5C3_CORP1 Hypothetical protein 111234,6 1,49 0.946918
  D9Q700_CORP1 Hypothetical protein 2467,24 1,49 0.072810
  D9Q657_CORP1 Hypothetical protein 1172,66 1,41 0.830926
  D9Q6F2_CORP1 Hypothetical protein 2467,24 1,34 0.061860
  D9Q7X5_CORP1 Hypothetical protein 38716,45 −1,21 0.825761
  D9Q4T9_CORP1 Hypothetical protein 553,76 −1,28 0.934591
  D9Q6R6_CORP1 Hypothetical protein 1457,62 −1,40 0.206908
  D9Q890_CORP1 Hypothetical protein 1948,52 −1,51 0.847549
  D9Q6M6_CORP1 Hypothetical proteinc 1935,68 −1,90 0.823541
 Others
  D9Q6I3_CORP1 Maltotriose binding protein 5210,9 5,22 0.864851
  D9Q4A3_CORP1 DsbG protein 3101,13 2,06 0.814366
  D9Q6N9_CORP1 D methionine binding lipoprotein metQ 2665,58 1,79 0.764416
  D9Q732_CORP1 Carbonic anhydraseb 689,15 1,66 0.130559
  D9Q6W6_CORP1 Lipoprotein LpqB 1484,31 1,63 0.670057
  D9Q556_CORP1 LSR2 like protein 2714,21 1,49 0.096802
  D9Q5Q0_CORP1 UPF0145 protein 2467,24 1,37 0.025009
  D9Q7W0_CORP1 Hypothetical protein 2467,24 1,26 0.039678
  D9Q701_CORP1 UPF0182 protein 1682,98 1,26 0.869411
  D9Q8A3_CORP1 Protein yceIb 16885,01 1,21 0.901679
  D9Q5X4_CORP1 Serine aspartate repeat containing protein 528,36 −1,82 0.892317
  D9Q826_CORP1 DoxX family protein 697,26 −2,08 0.614317
  D9Q7W3_CORP1 Mycothiol acetyltransferase 947,33 −2,11 0.214833
  D9Q407_CORP1 Ornithine cyclodeaminase 2566,18 −2,58 0.048247
  1. aFold change - Ratio values to: 1002Rc:11002Ct_Log(2)Ratio ≥ 1.2 proteins with p < 0.05
  2. bIdentified in an isolated of C. pseudotuberculosis from ovine lymph nodes [Rees et al. [12]
  3. cInduced in 1002_ovis during to stress nitrosative [Pacheco et al. [57], Silva et al. [58]
  4. dPredicted LPXTG cell wall-anchoring motif