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Table 4 Antimicrobial activity and statistical data

From: Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii

Peptide

Bacteria

MIC (μg/ml)

EC50 (μg/ml)

95 % CI (μg/ml)

EC50 (μM)

Apo5

E. coli ATCC 4157

NT

19.7

13.1 to 29.6

6.35

E. coli ATCC 51659

>250

13.9

10.7 to 18.0

4.48

S. aureus ATCC BAA-1718

NT

4.96

2.82 to 8.72

1.60

S. aureus ATCC 33592

>250

0.0680

0.124 to 0.357

0.0219

P. aeruginosa PAO1

>250

0.0878

0.0326 to 0.237

0.0283

P. aeruginosa ATCC BAA-2110

NT

0.467

0.234 to 0.934

0.150

A. baumannii ATCC 9955

NT

0.644

0.480 to 0.865

0.207

A. baumannii ATCC BAA-1794

>250

0.234

0.122 to 0.450

0.0755

Apo6

E. coli ATCC 4157

NT

3.85

2.71 to 5.48

1.39

E. coli ATCC 51659

>250

9.07

7.11 to 11.6

3.28

S. aureus ATCC BAA-1718

NT

2.31

1.69 to 3.16

0.835

S. aureus ATCC 33592

>250

0.883

0.526 to 1.48

0.319

P. aeruginosa PAO1

>250

1.17

0.866 to 1.62

0.429

P. aeruginosa ATCC BAA-2110

NT

0.130

0.100 to 0.168

0.0470

A. baumannii ATCC 9955

NT

0.233

0.129 to 0.419

0.0842

A. baumannii ATCC BAA-1794

>250

0.126

0.0899 to 0.176

0.126

A1P

E. coli ATCC 4157

NT

9.2

5.90 to 14.4

2.24

E. coli ATCC 51659

>250

2.51

1.55 to 4.08

0.611

S. aureus ATCC BAA-1718

NT

36.5

25.1 to 53.1

8.89

S. aureus ATCC 33592

>250

2.68

1.51 to 4.76

0.653

P. aeruginosa PAO1

>250

38.6

4.01 to 372

9.4

P. aeruginosa ATCC BAA-2110

NT

>800

 

>195

A. baumannii ATCC 9955

NT

24.0

1.52 to 7.19

5.84

A. baumannii ATCC BAA-1794

>250

2.36

0.370 to 1.75

0.575

LL-37

E. coli ATCC 4157

NT

0.191

0.109 to 0.337

0.0425

E. coli ATCC 51659

>250

0.298

0.208 to 0.428

0.0663

S. aureus ATCC BAA-1718

NT

0.839

0.497 to 1.42

0.187

S. aureus ATCC 33592

>250

0.208

0.138 to 0.312

0.0462

P. aeruginosa PAO1

>250

0.647

0.598 to 6.96

0.144

P. aeruginosa ATCC BAA-2110

NT

2.26

1.50 to 3.41

0.503

A. baumannii ATCC 9955

NT

1.46

1.04 to 2.07

0.825

A. baumannii ATCC BAA-1794

>250

0.804

0.370 to 1.75

0.179

Polymyxin B

E. coli ATCC 4157

NT

2.50

0.831 to 7.50

1.92

E. coli ATCC 51659

NT

0.00181

0.00135 to 0.00244

0.00139

P. aeruginosa PAO1

NT

0.00568

0.00458 to 0.00704

0.00436

P. aeruginosa ATCC BAA-2110

NT

0.0109

0.00706 to 0.0157

0.00837

A. baumannii ATCC 9955

NT

0.121

0.0895 to 0.164

0.0013

A. baumannii ATCC BAA-1794

NT

0.0131

0.0111 to 0.0153

0.0101

Vancomycin

S. aureus ATCC BAA-1718

1

>100

 

>69.0

S. aureus ATCC 33592

1

>100

 

>69.0

  1. MIC is determined in Mueller Hinton Broth II. EC50 is determined in 10 mM sodium phosphate buffer. NT Not Tested
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