From: Evaluation of fliC-d based direct blood PCR assays for typhoid diagnosis
Tests | Sensitivity (%, 95 % CI) | Specificity (%, 95 % CI) | PPV (%, 95 % CI) | NPV (%, 95 % CI) | LR+(95 % CI) | LR-(95 % CI) | Efficiency (%) |
---|---|---|---|---|---|---|---|
Culture | 24/81, 29.6 (20.0–40.8) | 29/29, 100.0 (87.9–100.0) | 24/24, 100.0 (85.6–100.0) | 29/86, 33.7 (23.9–44.7) | 29.6/0, ∞ | 70.4/100, 0.70 (0.61–0.81) | 53/110, 48.2b, c |
N-PCR | 66/81, 81.5 (71.3–89.2) | 29/29, 100.0 (87.9–100.0) | 66/66, 100.0 (88.3–100.0) | 28/44, 65.9 (49.0–79.0) | 81.5/0, ∞ | 18.5/100, 0.19 (0.12–0.3) | 95/110, 86.4b, d |
Q-PCR | 74/81, 91.4 (83.0–96.4) | 29/29, 100.0 (84.4–100.0) | 74/74, 100.0 (95.0–100.0) | 29/36, 80.6 (64.0–91.8) | 91.4/0, ∞ | 8.6/100, 0.09 (0.04–0.18) | 103/110, 93.6c, d |