Table 2 oprD genotypes among 78 bacteremic IRPA isolates
Major types of mutationa | No. of isolate | Description |
|---|---|---|
Amino acid frameshift produced by 1- and 2-bp insertion or deletion | 10 | Deletion of: 1 bp (G) at nt 311; 2 bp (TG) at nt 407-408; 1 bp (C) at nt 456 (2 isolates) Insertion of: 1 bp (G) at nt 555; 1 bp (T) at nt 977; 2 bp (AC) at nt 1050-1051 (2 isolates); 1 bp (C) at nt 1205 (2 isolates) |
Amino acid frameshift produced by partial deletion | 5 | 11-bp deletion beginning at nt 140, nt 175, nt 473 13-bp deletion beginning at nt 175, nt 208 |
Premature stop codon (point mutation) | 14 | CAG → TAG at nt 55-57, nt 472-474, nt 883-885, nt 1270-1272 (3 isolates) TGG → TAG at nt 193-195 TGG → TAG at nt 829-831 (3 isolates) TGG → TGA at nt 829-831 TGG → TAG at nt 1015-1017 (2 isolates) TAT → TAG at nt 1048-1050 |
Interruption by IS | 10 | Transposase at nt 37, 50 (2 isolates), 271, 434, 562, 571, 623, 652, 694 |
Amino acid substitution | 19 | Polymorphisms: D43N, S57E, S59R, T103S, K115T, V127L, F170L, E185Q, P186G, V189T, E202Q, I210A, E230K, D231N, S240T, L246V, D249E, L252V, N262T, R310E, A315G, S403A, Q424E, and G425A |
Shortening of putative loop L7 | 18 | Putative loop L7 (372 V-DSSSSYAGL-Y384) |
Identical | 2 | - |