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Table 2 Determination of compound sensitivity by disc diffusion assay

From: The GAS PefCD exporter is a MDR system that confers resistance to heme and structurally diverse compounds

Compounds

Zone of clearance (mm)

WT (NZ131)

Mutant (ZE4951)

Complement (ZE4951/pANKITA5b)

Control (ZE4951/pKSM201)

Heme

11.8 ± 1.4

15.8 ± 1.53a

9 ± 0.23

13 ± 0.31b

Doxorubicin

16

23 ± 1.25a

17 ± 0.19

22 ± 1.27b

Ethidium Bromide

22.5 ± 0.7

28.8 ± 0.35a

24

29 ± 1.4b

Hoechst 33342

18

22.8 ± 0.3a

19.5 ± 1.8

23.2 ± 1.0b

Ampicillin

44.8 ± 1.8

50.7 ± 1.1a

45.5 ± 0.8

49.7 ± 1.15b

Erythromycin

32 ± 1.0

38.7 ± 0.57a

33.3 ± 1.5

40.33 ± 1.52b

Norfloxacin

14

14

14.25 ± 0.35

13.75 ± 0.35

  1. The letters ‘a’ and ‘b’ represent P values of statistical significance at 0.05 level of significance calculated using student t-test (of equal variance). The statistical significance was evaluated by comparing WT with Mutant & Complement with Control data set
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BMC Microbiology

ISSN: 1471-2180

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