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Table 2 Determination of compound sensitivity by disc diffusion assay

From: The GAS PefCD exporter is a MDR system that confers resistance to heme and structurally diverse compounds

Compounds Zone of clearance (mm)
WT (NZ131) Mutant (ZE4951) Complement (ZE4951/pANKITA5b) Control (ZE4951/pKSM201)
Heme 11.8 ± 1.4 15.8 ± 1.53a 9 ± 0.23 13 ± 0.31b
Doxorubicin 16 23 ± 1.25a 17 ± 0.19 22 ± 1.27b
Ethidium Bromide 22.5 ± 0.7 28.8 ± 0.35a 24 29 ± 1.4b
Hoechst 33342 18 22.8 ± 0.3a 19.5 ± 1.8 23.2 ± 1.0b
Ampicillin 44.8 ± 1.8 50.7 ± 1.1a 45.5 ± 0.8 49.7 ± 1.15b
Erythromycin 32 ± 1.0 38.7 ± 0.57a 33.3 ± 1.5 40.33 ± 1.52b
Norfloxacin 14 14 14.25 ± 0.35 13.75 ± 0.35
  1. The letters ‘a’ and ‘b’ represent P values of statistical significance at 0.05 level of significance calculated using student t-test (of equal variance). The statistical significance was evaluated by comparing WT with Mutant & Complement with Control data set