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Table 1 Anti-HIV-1 activity of SJP-L-5

From: SJP-L-5, a novel small-molecule compound, inhibits HIV-1 infection by blocking viral DNA nuclear entry

Strainsa Subtypes Tropisms EC50 (Mean ± SD)b
SJP-L-5(μg/ml) AZTc(ng/ml)
HIV-1IIIB B X4 0.16 ± 0.03 29.7 ± 9.7
HIV-1MN B X4 0.97 ± 0.13 0.9 ± 0.1
HIV-1RF B X4 0.18 ± 0.04 80.0 ± 25.5
HIV-1KM018 CRF07_BC R5 2.32 ± 0.41 37.7 ± 15.1
HIV-1TC-2 CRF01_AE X4 1.96 ± 0.22 5.0 ± 1.6
HIV-1WAN CRF07_BC/CRF01_AE X4 5.33 ± 0.85 4.4 ± 1.5
  1. aHIV-1IIIB, HIV-1MN and HIV-1RF are lab-adapted strains that infect C8166 cells, and they were used to measure the antiviral activity of SJP-L-5; HIV-1KM018, HIV-1TC-2, and HIV-1WAN are clinical isolates that infect PBMC cells, and they were also used to measure the antiviral activity of SJP-L-5
  2. bn ≥ 3
  3. cAZT, azidothymidine