From: Automated image analysis for quantification of filamentous bacteria
E. coli ATCC 25922 | ESBL-producing E. coli | Blood culture E. coli | |||||||
---|---|---|---|---|---|---|---|---|---|
β-lactam antibiotics or β-lactam–β-lactamase inhibitor combinations | AIF | MIC | TTR | AIF | MIC | TTR | AIF | MIC | TTR |
conc. | (min) | conc. | (min) | conc. | (min) | ||||
ampicillin/sulbactam 2:1 ratio | 2/1–8/4 | 4/2 | 97 ± 3.33 | 16/8 | 16/8 | 100 ± 0 | 2/1–8/4 | ≤2/1 | 113 ± 6.67 |
aztreonam | All | ≤ 2 | 115 ± 5 | N.D. | >16 | 65 ± 5 | All | ≤ 2 | 103 ± 1.67 |
carbenicillin | 32–128 | ≤ 32 | 102 ± 1.67 | N.D. | 256 | 55 ± 5 | All | ≤ 32 | 60 ± 0 |
cefepime | 2–4 | ≤ 2 | 103 ± 1.67 | All | 4 | 117 ± 3.33 | 2–4 | ≤ 2 | 132 ± 6.01 |
cefoperazone | All | ≤ 4 | 117 ± 3.33 | All | 8 | 133 ± 6.67 | All | ≤ 4 | 155 ± 5 |
cefotaxime | 4–8 | ≤ 4 | 102 ± 1.67 | All | ≤ 4 | 103 ± 1.67 | 4–8 | ≤ 4 | 93 ± 3.33 |
ceftazidime | All | ≤ 1 | 133 ± 6.67 | N.D. | >16 | 62 ± 1.67 | All | ≤ 1 | 117 ± 3.33 |
ceftriaxone | 4–8 | ≤ 4 | 93 ± 3.33 | All | ≤4 | 115 ± 5 | 4–8 | ≤ 4 | 97 ± 3.33 |
piperacillin | All | ≤ 8 | 103 ± 1.67 | N.D. | >64 | 55 ± 5 | All | ≤ 8 | 163 ± 1.67 |
piperacillin/tazobactam constant four | All | ≤ 8/4 | 113 ± 6.67 | F | ≤8/4 | 162 ± 1.67 | All | ≤ 8/4 | 115 ± 5 |
ticarcillin | All | ≤ 8 | 123 ± 3.33 | N.D. | >64 | 65 ± 5 | All | ≤ 8 | 100 ± 0 |
ticarcillin/clavulanic acid constant two | 16/2–32/2 | 8/2 | 138 ± 1.67 | N.D. | 128/2 | 163 ± 1.67 | 16/2–64/2 | ≤ 16/2 | 102 ± 1.67 |