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Table 1 Effect of TZ on EP substrates MICs before and after the exposure processes

From: Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus

MIC (mg/L) after exposure to:
    EtBr CIP CET
  Original MIC (mg/L) ½ MIC MIC ½ MIC MIC ½ MIC MIC
  No EI + TZ No EI + TZ No EI + TZ No EI + TZ No EI + TZ No EI + TZ No EI + TZ
ATCC25923
EtBr 8 1 (↓8x) 32 4 (↓8x) 32 1 (↓32x) 32 8 (↓4x) 32 4 (↓8x) 8 2 (↓4x) 32 4 (↓8x)
CIP 0.25 0.125 (↓2x) 2 0.25 (↓8x) 2 0.25 (↓8x) 2 0.5 (↓4x) 2 0.5 (↓4x) 0.5 0.25 (↓2x) 2 0.5 (↓4x)
CET 2 0.25 (↓8x) 4 0.5 (↓8x) 8 0.125 (↓64x) 4 0.5 (↓8x) 4 0.5 (↓8x) 4 0.5 (↓8x) 4 0.5 (↓8x)
SM2
EtBr 8 2 (↓4x) 32 1 (↓32x) 64 2 (↓32x) 32 4 (↓8x) 32 2 (↓16x) 8 1 (↓8x) 32 4 (↓8x)
CIP 32 16 (↓2x) 128 16 (↓8x) 512 32 (↓16x) 256 32 (↓8x) 256 16 (↓16x) 32 8 (↓4x) 128 32 (↓4x)
CET 2 0.5 (↓4x) 4 0.25 (↓16x) 16 4 (↓4x) 4 2 (↓2x) 8 1 (↓8x) 4 0.5 (↓8x) 8 2 (↓4x)
SM50
EtBr 8 1 (↓8x) 64 8 (↓8x) 32 8 (↓4x) 64 4 (↓16x) 32 4 (↓8x) 16 2 (↓8x) --- ---
CIP 64 16 (↓4x) 256 64 (↓4x) 256 64 (↓4x) 512 64 (↓8x) 256 64 (↓4x) 128 32 (↓4x) --- ---
CET 4 0.5 (↓8x) 8 1 (↓8x) 8 1 (↓8x) 8 2 (↓4x) 8 2 (↓4x) 4 1 (↓4x) --- ---
  1. The values in brackets correspond to the decrease (↓ n-fold) of the MICs in the presence of a sub-inhibitory concentration of TZ relatively to the original values (absence of efflux inhibitor); decreases of  ≥ 4-fold are highlighted by bold-type letters