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Figure 2 | BMC Microbiology

Figure 2

From: Caspase-3-independent apoptotic pathways contribute to interleukin-32γ-mediated control of Mycobacterium tuberculosis infection in THP-1 cells

Figure 2

Cathepsins contribute to the anti- MTB effects of IL-32γ. A) THP-1 cells were infected with MTB alone, MTB + IL-32γ (50 ng/mL), or pre-incubated with combined cathepsin B and D inhibitors or with cathepsin L inhibitor for one hour and then incubated with MTB + IL-32γ. Intracellular CFU were quantified in one hour, two days, and four days after infection. B) TUNEL positive cells were quantified two days after MTB infection ± IL-32γ (50 ng/mL) with and without cathepsin B/D inhibitors or cathepsin L inhibitor. Data shown are the mean ± SEM of four independent experiments. *p < 0.05, **p < 0.01.

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BMC Microbiology

ISSN: 1471-2180

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