Table 2 In vitro activity (MIC 50 , MIC 90 , and MIC range, μg/L) and percentage of H. influenzae isolates that were susceptible (S), intermediate (I), or resistant (R) to antibiotic agents during the study period
Antibiotics agents | Year | MIC 50 | MIC 90 | MIC range | S (%) | I (%) | R (%) |
|---|---|---|---|---|---|---|---|
Ampicillin (AMP) | 2000 | 0.19 | 0.44 | 0.064–256 | 96 | 0 | 4.0 |
2002 | 0.25 | 1 | 0.064–256 | 87 | 0 | 13.0 | |
2010 | 0.75 | 256 | 0.064–256 | 63.0 | 9.9 | 27.1 | |
2012 | 0.75 | 256 | 0.064–256 | 61.2 | 7.8 | 31.0 | |
Amoxicillin / clavulanic acid (AMC) | 2000 | 0.5 | 0.75 | 0.19–3 | 100 | 0 | 0 |
2002 | 0.5 | 1 | 0.064–4 | 100 | 0 | 0 | |
2010 | 0. 5 | 2 | 0. 19–3 | 100 | 0 | 0 | |
2012 | 0.75 | 3 | 0. 19–8 | 97.8 | 0 | 2.7 | |
Cefaclor (CFC) | 2000 | 1.5 | 2 | 0.5–48 | 98.0 | 1.0 | 1.0 |
2002 | 1 | 2 | 0.38–48 | 95.0 | 2.0 | 3.0 | |
2010 | 1.5 | 16 | 0.5–128 | 87.2 | 5.7 | 7.1 | |
2012 | 1.5 | 12 | 0.5–256 | 81.0 | 6.8 | 12.2 | |
Cefuroxime (CXM) | 2000 | 0.5 | 0.75 | 0.19–4 | 100 | 0 | 0 |
2002 | - | - | - | 99 | 1.0 | 0 | |
2010 | 0.75 | 1 | 0.75–4 | 97.1 | 2.9 | 0 | |
2012 | 0.75 | 1 | 0.75–4 | 91.9 | 2.7 | 5.4 | |
Ceftriaxone (CRO) | 2000 | 0.004 | 0.006 | 0.002–0.032 | 100 | 0 | 0 |
2002 | - | - | 99 | 1.0 | 0 | ||
2010 | 0.008 | 0.016 | - | 100 | 0 | 0 | |
2012 | 0.016 | 0.047 | 0.004–0.032 | ||||
0.016–0.75 | 100 | 0 | 0 | ||||
Tetracycline (TCY) | 2000 | - | - | - | 60.0 | 23.0 | 17.0 |
2002 | - | - | - | 54.0 | 24.0 | 22.0 | |
2010 | - | - | - | 91.5 | 7.1 | 1.4 | |
2012 | - | - | - | 94.5 | 4.1 | 1.4 | |
Sulfamethoxazole (SXT) | 2000 | - | - | - | 21.0 | 0 | 79.0 |
2002 | - | - | - | 37.0 | 1.0 | 62.0 | |
2010 | - | - | - | 22.9 | 1.4 | 75.7 | |
2012 | - | - | - | 28.4 | 2.7 | 68.9 | |
Chloramphenicol (CHL) | 2000 | - | - | - | 93.0 | 1.0 | 6.0 |
2002 | - | - | - | 87.0 | 1.0 | 12.0 | |
2010 | - | - | - | 88.6 | 11.4 | 0 | |
2012 | - | - | - | 95.9 | 0 | 4.1 |