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Table 1 Differentially expressed miRNAs identified to be commonly presented in w81-infected mouse lungs at both 1 dpi and 3 dpi

From: Differential microRNA expression following infection with a mouse-adapted, highly virulent avian H5N2 virus

miRNA w81‡
1dpi 3dpi
Fold change* P value§ Fold change P value
let-7e-3p 2.6 0.008 2.3 0.006
miR-100-5p† 2.1 0.005 2.6 0
miR-10a-5p 2.1 0.009 2 0.002
miR-130a-5p† 3.4 0.036 3.2 0.01
miR-146b-3p† 3.1 0.014 4.7 0.003
miR-147-3p† 2.7 0.013 22.8 0.012
miR-148a-5p 2.3 0.029 2.4 0.002
miR-151-5p† 4.5 0.013 2.7 0.014
miR-155-3p† 2.3 0.015 3.5 0.016
miR-1843-3p 3.6 0.022 3.1 0.007
miR-1943-3p 4 0.01 4.3 0.049
miR-223-3p† 3.5 0.037 3.4 0.009
miR-28-3p 2 0.021 2.4 0.001
miR-301a-3p† −6.9 0.019 −2 0.048
miR-3079-5p 2.8 0.035 2.4 0.034
miR-30b-5p 2 0.024 2.6 0.007
miR-30c-5p 2.5 0.038 2.2 0.024
miR-324-5p 2.1 0.02 3.1 0
miR-335-3p 2.1 0.004 2.7 0.003
miR-3475-3p 2.8 0.019 2.5 0.008
miR-365-3p 2.1 0.012 2.2 0.016
miR-495-3p† 2 0.042 2.9 0.01
miR-652-3p 3.9 0.042 2.8 0.011
miR-674-3p 2.5 0.019 2.2 0.001
miR-99b-5p 3.1 0.007 2.5 0
  1. ‡ global cellular miRNA expression patterns in mouse lungs infected with w81 were compared with those of uninfected control mouse lungs. Differentially expressed miRNAs with a p < 0.05 and fold change>2 are described.
  2. *Sequence reads were normalized to determine the number of transcripts per million (TPM) using the following formula: Normalized expression = Actual miRNA count/Total count of clean reads*1000000. Then, fold changes of miRNAs were evaluated using the following formula: Fold change = log2 (treatment/control).
  3. §P-value was calculated from the normalized expression values as previously described [66].
  4. †Significantly upregulated in both lungs infected with either wild type w81 or the mouse-adapted ma81 strain at all time points.