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Table 2 Top 20 differentially regulated genes in gingival tissues according to subgingival levels of A. actinomycetemcomitans, P. gingivalis and C. rectus.

From: Subgingival bacterial colonization profiles correlate with gingival tissue gene expression

Rank A. actinomycetemcomitans   P. gingivalis   C. rectus  
  Genea FCb Gene FC Gene FC
1 hypothetical protein MGC29506 5.76 hypothetical protein MGC29506 11.21 hypothetical protein MGC29506 9.04
2 tumor necrosis factor receptor superfamily, member 17 4.23 non-annotated 8.64 non-annotated 7.62
3 sperm associated antigen 4 4.01 tumor necrosis factor receptor superfamily, member 17 7.92 tumor necrosis factor receptor superfamily, member 17 6.48
4 interferon, alpha-inducible protein 6 3.91 immunoglobulin kappa variable 1-5 7.59 POU domain, class 2, associating factor 1 6.37
5 POU domain, class 2, associating factor 1 3.86 non-annotated 7.51 immunoglobulin heavy variable 1-69 6.34
6 CD79a molecule, immunoglobulin-associated alpha 3.65 immunoglobulin kappa variable 1-5 7.42 sperm associated antigen 4 6.14
7 FK506 binding protein 11, 19 kDa 3.58 immunoglobulin heavy variable 1-69 7.41 KIAA0125 6.10
8 hypothetical protein MGC29506 3.56 interferon, alpha-inducible protein 6 7.38 interferon, alpha-inducible protein 6 5.93
9 immunoglobulin lambda locus, immunoglobulin lambda constant 1 3.50 POU domain, class 2, associating factor 1 7.18 immunoglobulin kappa constant, immunoglobulin kappa variable 1-5 5.92
10 immunoglobulin heavy constant alpha 1 3.47 immunoglobulin kappa variable 1-5 7.16 interferon, alpha-inducible protein 6 5.72
11 KIAA0746 protein 3.41 interferon, alpha-inducible protein 6 6.97 immunoglobulin heavy constant alpha 1 5.65
12 CD79a molecule, immunoglobulin-associated alpha 3.39 non-annotated 6.96 Fc receptor-like 5 5.60
13 family with sequence similarity 46, member C 3.34 immunoglobulin heavy constant alpha 1 6.89 non-annotated 5.55
14 non-annotated 3.34 interferon, alpha-inducible protein 6 6.87 interferon, alpha-inducible protein 6 5.53
15 interferon, alpha-inducible protein 6 3.26 Fc receptor-like 5 6.85 interferon, alpha-inducible protein 6 5.52
16 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 3.20 KIAA0125 6.79 immunoglobulin lambda locus, immunoglobulin lambda constant 1 (Mcg marker) 5.49
17 immunoglobulin lambda locus, immunoglobulin lambda constant 1 (Mcg marker) 3.16 immunoglobulin kappa variable 1-5 6.70 interferon, alpha-inducible protein 6, immunoglobulin heavy locus (G1m marker) 5.39
18 KIAA0746 protein 3.12 immunoglobulin lambda locus 6.67 non-annotated 5.37
19 SLAM family member 7 3.11 immunoglobulin lambda locus, immunoglobulin lambda constant 1 (Mcg marker) 6.63 immunoglobulin lambda locus, immunoglobulin lambda constant 1 (Mcg marker) 5.36
20 interferon, alpha-inducible protein 6 3.03 sperm associated antigen 4 6.59 immunoglobulin kappa constant, immunoglobulin kappa variable 1-5 5.35
  1. aRepeated occurrence of the same gene among the top ranked is due to multiple probe sets mapping to the same gene
  2. bFold change indicates ratio of expression in gingival tissues in the upper over the lower quintile of colonization by the particular species