The highly conserved serine threonine kinase StkP of Streptococcus pneumoniae contributes to penicillin susceptibility independently from genes encoding penicillin-binding proteins

Table 3 Resistance phenotype and transformability of RX derivatives with different combinations of PBP and StkP alleles

Strain	Genotype	MIC Pen^a (μg ml^-1)
URA1258	Multiresistant strain closely related to Spain 23F-1 clone	0.5–1
Cp1015	Rx derivate, str1; hexA	0.016
Cp7000	Cp1015, stkP::cat	0.008
Pen1	Cp1015, penA and pbpX from URA1258, allelic exchange mutant	0.064 – 0.125
Pen2	Cp1015, penA, pbpX and pbp1A from URA1258, allelic exchange mutant	0.38 – 0.5
Pen1STK	Pen1, stkP::cat	0.016 – 0.032
Pen2STK	Pen2, stkP::cat	0.032 – 0.125

^a: MIC Pen, Minimum inhibitory concentration for penicillin. ND, not determined.

ISSN: 1471-2180