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Table 1 Minimal fungicidal concentration (MFC) values of Candida and Aspergillus strains to AMB (amphotericin B), FLC (fluconazole), ITC (itraconazole), VRC (voriconazole) and PSC (posaconazole), determined by CLSI protocols, in the absence and presence of propofol infusion

From: Propofol lipidic infusion promotes resistance to antifungals by reducing drug input into the fungal cell

   Strains (n)
   MFC values* range μg.ml-1
Antifungals Propofol(mg.ml-1) C. albicans (5) C. tropicalis (5) C. parapsilosis (5) C. glabrata (5) A. fumigatus (5) A. flavus (4) A. niger (4)
AMB 0 0.25 0.25–1 0.06–0.125 0.25–0.5 0.25–0.5 0.5–1 0.06–0.25
  1.25 0.5–1 1 2 2 1–4 1–>16 0.25–1
  2.5 0.5–2 1–2 2 2 2–4 1–>16 0.25–1
  5 2–4 2 2–8 4–8 4–16 4–>16 0.5–2
FLC 0 8–16 4–8 8–16 16 nd nd nd
  1.25 16–>64 >64 >64 >64 nd nd nd
  2.5 16–>64 >64 >64 >64 nd nd nd
  5 16–>64 >64 >64 >64 nd nd nd
ITC 0 nd nd nd nd 0.5–16 0.125–0.25 0.125–16
  1.25 nd nd nd nd >16 2–>16 >16
  2.5 nd nd nd nd >16 8–>16 >16
  5 nd nd nd nd >16 16–>16 >16
VRC 0 0.06–0.25 0.25–0.5 0.5–1 4–8 0.25–4 0.25–2 0.06–8
  1.25 0.25–>2 >2 >2 >8 2–8 0.25–2 1–16
  2.5 0.5–>2 >2 >2 >8 2–8 0.5–4 1–16
  5 1–>2 >2 >2 >8 2–8 0.5–4 1–16
PSC 0 0.06–0.125 0.03–0.125 0.06–0.125 1–2 0.03–0.25 0.03–0.06 0.06–1
  1.25 1–2 >2 2 2 1–4 0.25–2 0.125–8
  2.5 >2 >2 2 >2 1–4 0.5–2 0.25–16
  5 >2 >2 >2 >2 1–4 0.5–4 0.25–>16
  1. nd not done
  2. * The mean value for each strain was considered