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Table 5 Time kill curve against β-lactamase negative-ampicillin resistant H. influenzae (n = 10)

From: In vitro activity of telithromycin against Haemophilus influenzae at epithelial lining fluid concentrations

Antibiotic

 

Changes in colony counts vs initial inocula after

  

3 h

6 h

12 h

24 h

  

CO2

Air

CO2

Air

CO2

Air

CO2

Air

Telithromycin

4 × MIC

-1.53

-1.96

-2.38

-2.69

> -3.0

> -3.0

> -3.0

> -3.0

 

2 × MIC

-0.68

-0.30

-1.55

-1.96

-2.82

-2.84

> -3.0

> -3.0

 

1 × MIC

-0.38

-0.56

-0.88

-0.66

-1.23

-1.27

-1.66

-1.37

 

1/2 × MIC

0.17

0.78

2.26

2.43

2.94

3.26

3.53

4.40

 

1/4 × MIC

0.33

0.92

2.66

2.68

3.26

3.30

3.64

4.51

 

ELF

-0.55

-0.92

-2.85

-2.89

> -3.0

> -3.0

> -3.0

> -3.0

Clarithromycin

4 × MIC

-1.68

-0.96

-2.02

-1.96

> -3.0

> -3.0

> -3.0

> -3.0

 

2 × MIC

-0.16

-0.62

-1.16

-1.38

-1.70

-1.99

> -3.0

> -3.0

 

1 × MIC

-0.14

-0.21

-0.45

-0.42

-1.56

-0.67

-1.75

-1.74

 

1/2 × MIC

0.33

0.51

1.76

1.34

1.99

1.45

3.51

4.28

 

1/4 × MIC

0.64

0.75

2.87

2.88

3.44

3.35

4.03

4.61

 

ELF

-0.71

-1.36

-2.43

-2.62

> -3.0

> -3.0

> -3.0

> -3.0

Azithromycin

4 × MIC

-1.55

-1.62

-2.50

-2.76

> -3.0

> -3.0

> -3.0

> -3.0

 

2 × MIC

-1.16

-1.37

-1.90

-1.96

> -3.0

> -3.0

> -3.0

> -3.0

 

1 × MIC

-1.01

-0.56

-0.90

-0.89

-1.68

-1.06

-1.78

-1.59

 

1/2 × MIC

0.21

0.72

0.92

1.28

1.98

2.01

2.49

2.53

 

1/4 × MIC

0.27

0.79

2.54

2.04

3.04

3.14

3.72

4.16

 

ELF

-1.12

-1.40

-2.57

-2.73

-2.83

> -3.0

> -3.0

> -3.0

Control

 

0.97

0.98

3.07

3.01

3.87

3.46

5.05

4.68