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Table 5 Time kill curve against β-lactamase negative-ampicillin resistant H. influenzae (n = 10)

From: In vitro activity of telithromycin against Haemophilus influenzae at epithelial lining fluid concentrations

Antibiotic   Changes in colony counts vs initial inocula after
   3 h 6 h 12 h 24 h
   CO2 Air CO2 Air CO2 Air CO2 Air
Telithromycin 4 × MIC -1.53 -1.96 -2.38 -2.69 > -3.0 > -3.0 > -3.0 > -3.0
  2 × MIC -0.68 -0.30 -1.55 -1.96 -2.82 -2.84 > -3.0 > -3.0
  1 × MIC -0.38 -0.56 -0.88 -0.66 -1.23 -1.27 -1.66 -1.37
  1/2 × MIC 0.17 0.78 2.26 2.43 2.94 3.26 3.53 4.40
  1/4 × MIC 0.33 0.92 2.66 2.68 3.26 3.30 3.64 4.51
  ELF -0.55 -0.92 -2.85 -2.89 > -3.0 > -3.0 > -3.0 > -3.0
Clarithromycin 4 × MIC -1.68 -0.96 -2.02 -1.96 > -3.0 > -3.0 > -3.0 > -3.0
  2 × MIC -0.16 -0.62 -1.16 -1.38 -1.70 -1.99 > -3.0 > -3.0
  1 × MIC -0.14 -0.21 -0.45 -0.42 -1.56 -0.67 -1.75 -1.74
  1/2 × MIC 0.33 0.51 1.76 1.34 1.99 1.45 3.51 4.28
  1/4 × MIC 0.64 0.75 2.87 2.88 3.44 3.35 4.03 4.61
  ELF -0.71 -1.36 -2.43 -2.62 > -3.0 > -3.0 > -3.0 > -3.0
Azithromycin 4 × MIC -1.55 -1.62 -2.50 -2.76 > -3.0 > -3.0 > -3.0 > -3.0
  2 × MIC -1.16 -1.37 -1.90 -1.96 > -3.0 > -3.0 > -3.0 > -3.0
  1 × MIC -1.01 -0.56 -0.90 -0.89 -1.68 -1.06 -1.78 -1.59
  1/2 × MIC 0.21 0.72 0.92 1.28 1.98 2.01 2.49 2.53
  1/4 × MIC 0.27 0.79 2.54 2.04 3.04 3.14 3.72 4.16
  ELF -1.12 -1.40 -2.57 -2.73 -2.83 > -3.0 > -3.0 > -3.0
Control   0.97 0.98 3.07 3.01 3.87 3.46 5.05 4.68