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Table 1 MIC values of H. influenzae strains

From: In vitro activity of telithromycin against Haemophilus influenzae at epithelial lining fluid concentrations

Microorganisms Drug MIC
   Ambient air CO2
   Range (mg/L) MIC 50 /MIC 90 (mg/L) S (%) # Range (mg/L) MIC 50 /MIC 90 (mg/L) S (%) #
β-lactamase negative (n = 200) Tel § 0.03 – 4 1/2 100 0.06 – 16 2/8 82
  Clr 0.25 – 8 2/8 100 1 – 16 8/16 91
  Azm 0.25 – 2 1/2 100 0.5 – 8 2/4 88
β-lactamase positive (n = 50) Tel 0.06 – 4 1/2 100 0.125 – 8 2/8 87
  Clr 0.5 – 8 2/8 100 1 – 16 8/16 89
  Azm 0.25 – 2 1/2 100 0.5 – 8 2/4 89
BLNAR* (n = 10) Tel 0.06 – 4 1/4 100 0.125 – 8 2/8 90
  Clr 1 – 8 1/8 100 2 – 16 8/16 90
  Azm 0.25 – 4 1/4 100 0.5 – 8 2/8 80
  1. *: BLNAR: β-lactamase negative ampicillin resistant; §: Tel: telithromycin; Clr: Clarithromycin; Azm: Azithromycin. # S:susceptible strains according to CLSI breakpoints: Telithromycin: susceptibility: ≤ 4 mg/L, resistance: ≥ 16 mg/L; Clarithromycin: susceptibility: ≤ 8 mg/L, resistance: ≥ 32 mg/L; Azithromycin: susceptibility: ≤ 4 mg/L.