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Table 1 MIC values of H. influenzae strains

From: In vitro activity of telithromycin against Haemophilus influenzae at epithelial lining fluid concentrations

Microorganisms

Drug

MIC

  

Ambient air

CO2

  

Range (mg/L)

MIC 50 /MIC 90 (mg/L)

S (%) #

Range (mg/L)

MIC 50 /MIC 90 (mg/L)

S (%) #

β-lactamase negative (n = 200)

Tel §

0.03 – 4

1/2

100

0.06 – 16

2/8

82

 

Clr

0.25 – 8

2/8

100

1 – 16

8/16

91

 

Azm

0.25 – 2

1/2

100

0.5 – 8

2/4

88

β-lactamase positive (n = 50)

Tel

0.06 – 4

1/2

100

0.125 – 8

2/8

87

 

Clr

0.5 – 8

2/8

100

1 – 16

8/16

89

 

Azm

0.25 – 2

1/2

100

0.5 – 8

2/4

89

BLNAR* (n = 10)

Tel

0.06 – 4

1/4

100

0.125 – 8

2/8

90

 

Clr

1 – 8

1/8

100

2 – 16

8/16

90

 

Azm

0.25 – 4

1/4

100

0.5 – 8

2/8

80

  1. *: BLNAR: β-lactamase negative ampicillin resistant; §: Tel: telithromycin; Clr: Clarithromycin; Azm: Azithromycin. # S:susceptible strains according to CLSI breakpoints: Telithromycin: susceptibility: ≤ 4 mg/L, resistance: ≥ 16 mg/L; Clarithromycin: susceptibility: ≤ 8 mg/L, resistance: ≥ 32 mg/L; Azithromycin: susceptibility: ≤ 4 mg/L.
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BMC Microbiology

ISSN: 1471-2180

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