Colonization of various tissues by F. tularensis subsp. novicida. In order to determine the presence of F. tularensis subsp. novicida in the GI tract after i.n infection a Rif+ resistant strain was generated. Data represent an average of 3 mice per time point and are given as Log CFU/g of tissue. Lung, stomach, cecum, small intestine and large intestine were harvested at 2 hrs, 6 hrs and 20 hrs p.i and CFU were determined. The data obtained for each of the tissues sampled 2 hrs p.i was compared statistically by using a two tail Student's t-test to the data obtained 6 hrs and 20 hrs p.i. * = p < 0.05, ** = p < 0.01 and *** = p < 0.005.