Chromosomal distribution and orientation of σB-differential regulated genes. The first circle represents the scale in kb starting with the origin of replication at position 0. The second circle shows the distribution of coding sequences (CDS) of the leading and lagging strand in gray including σB-dependent up regulated genes in green and σB-dependent down regulated genes in red. The third circle indicates the COG classification for each gene and distribution of COG classes within the genome. Colour scheme and categories were chosen to the convention of the COG database. The innermost circle displays the GC skew ([G+C]/[G-C]), with values greater than zero in purple and less than zero in orange. For GC skew analysis we applied a sliding window of 1000 bp with an overlap of 500 bp. The figure was drawn using the GenomeViz software .