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Table 2 List of genes induced at 37°C shown or implicated to be associated with intracellular growth and/or virulence of F. tularensis.

From: Global transcriptional response to mammalian temperature provides new insight into Francisella tularensis pathogenesis

Locus tag Description, gene name (if available) Fold Change Reference
FTL_0028 Aspartate carbamoyltransferase, pyrB 2.2 [12, 14]
FTL_0029 Carbamoyl-phosphate synthase large chain, carB 2.6 [12, 14, 66]
FTL_0030 Carbamoyl-phosphate synthase small chain, carA 2.6 [12, 14]
FTL_0094 Chaperone, clpB 2.5 [13, 14, 27, 67, 68]
FTL_0198 Pyridoxal/pyridoxine/pyridoxamine kinase, pdxY 2.0 [14]
FTL_0267 Chaperone Hsp90, htpG 2.3 [14, 46, 66, 69]
FTL_0307 Dephospho-CoA kinase, coaE   [46, 69]
FTL_0337 Pseudogene with homology to miaB 2.1 [13]
FTL_0445 Hypothetical protein with homology to NADPH-dependent FMN reductase 2.5 [13, 46, 69]
FTL_0479 glycine cleavage system P protein, subunit 1, qcvP1 1.4 [14]
FTL_0671 Annotated as transcriptional regulator, homologous to Pantothenate kinase type III, coaX 2.3 [46, 69]
FTL_0672 Aspartate-1-decarboxylase, panD 2.0 [14, 46, 69]
FTL_0675 Conserved hypothetical protein 2.3 [46, 69]
FTL_0837 D-methionine binding transport protein, ABC transporter, membrane and periplasmic protein, metlQ 2.0 [13]
FTL_0885 PhoH-like protein 1.9 [14]
FTL_0886 Conserved hypothetical protein, yleA 1.8 [68]
FTL_0899 protease, GTP-binding subunit, hflX 1.8 [13]
FTL_0928 DJ-1/PfpI family protein 2.1 [13]
FTL_1048 Conserved hypothetical protein 1.8 [14]
FTL_1190 Chaperone protein (heat shock protein family 70 cofactor), grpE 1.7 [46, 69]
FTL_1338 Alanine racemase, alr 2.1 [67]
FTL_1474 transcriptional elongation factor, qreA 1.8 [13]
FTL_1485 Conserved hypothetical membrane protein 2.2 [46, 69]
FTL_1545 SNO glutamine amidotransferase family protein 2.6 [46, 69]
FTL_1546 Pyridoxine/pyridoxal 5-phosphate biosynthesis protein 2.2 [46, 69]
FTL_1553 Succinyl-CoA synthetase beta chain, sucC 1.6 [13]
FTL_1595 Dimethyladenosine transferase, kasugamycin resistance, ksgA 3.2 [14]
FTL_1664 Phosphopentomutase, deoB 2.1 [14]
FTL_1714 Chaperonin (Hsp60 family), groEL 3.2 [14]
FTL_1782 adenine phosphoribosyltransferase, apt 1.5 [14]
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