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Table 2 List of genes induced at 37°C shown or implicated to be associated with intracellular growth and/or virulence of F. tularensis.

From: Global transcriptional response to mammalian temperature provides new insight into Francisella tularensis pathogenesis

Locus tag

Description, gene name (if available)

Fold Change

Reference

FTL_0028

Aspartate carbamoyltransferase, pyrB

2.2

[12, 14]

FTL_0029

Carbamoyl-phosphate synthase large chain, carB

2.6

[12, 14, 66]

FTL_0030

Carbamoyl-phosphate synthase small chain, carA

2.6

[12, 14]

FTL_0094

Chaperone, clpB

2.5

[13, 14, 27, 67, 68]

FTL_0198

Pyridoxal/pyridoxine/pyridoxamine kinase, pdxY

2.0

[14]

FTL_0267

Chaperone Hsp90, htpG

2.3

[14, 46, 66, 69]

FTL_0307

Dephospho-CoA kinase, coaE

 

[46, 69]

FTL_0337

Pseudogene with homology to miaB

2.1

[13]

FTL_0445

Hypothetical protein with homology to NADPH-dependent FMN reductase

2.5

[13, 46, 69]

FTL_0479

glycine cleavage system P protein, subunit 1, qcvP1

1.4

[14]

FTL_0671

Annotated as transcriptional regulator, homologous to Pantothenate kinase type III, coaX

2.3

[46, 69]

FTL_0672

Aspartate-1-decarboxylase, panD

2.0

[14, 46, 69]

FTL_0675

Conserved hypothetical protein

2.3

[46, 69]

FTL_0837

D-methionine binding transport protein, ABC transporter, membrane and periplasmic protein, metlQ

2.0

[13]

FTL_0885

PhoH-like protein

1.9

[14]

FTL_0886

Conserved hypothetical protein, yleA

1.8

[68]

FTL_0899

protease, GTP-binding subunit, hflX

1.8

[13]

FTL_0928

DJ-1/PfpI family protein

2.1

[13]

FTL_1048

Conserved hypothetical protein

1.8

[14]

FTL_1190

Chaperone protein (heat shock protein family 70 cofactor), grpE

1.7

[46, 69]

FTL_1338

Alanine racemase, alr

2.1

[67]

FTL_1474

transcriptional elongation factor, qreA

1.8

[13]

FTL_1485

Conserved hypothetical membrane protein

2.2

[46, 69]

FTL_1545

SNO glutamine amidotransferase family protein

2.6

[46, 69]

FTL_1546

Pyridoxine/pyridoxal 5-phosphate biosynthesis protein

2.2

[46, 69]

FTL_1553

Succinyl-CoA synthetase beta chain, sucC

1.6

[13]

FTL_1595

Dimethyladenosine transferase, kasugamycin resistance, ksgA

3.2

[14]

FTL_1664

Phosphopentomutase, deoB

2.1

[14]

FTL_1714

Chaperonin (Hsp60 family), groEL

3.2

[14]

FTL_1782

adenine phosphoribosyltransferase, apt

1.5

[14]

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BMC Microbiology

ISSN: 1471-2180

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