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Table 5 Relationship between CCs identified by SNP typing, and genotype

From: Assignment of Streptococcus agalactiae isolates to clonal complexes using a small set of single nucleotide polymorphisms

CLONAL COMPLEX SNP PROFILE MOLECULAR SEROTYPE (MS)1 PROTEIN GENE PROFILE (PGP)1 MOBILE GENETIC ELEMENTS (MGE)1 N = 116 (SSI)2
CC 1 (n = 22) CTAG V Alp3 1S1381 10 (3)
   V Alp3 None 1
   V - GBSi1 1
   Ia Alp1 GBSi1 2
   Ia Alp1 IS861-GBSi1 1
   Ia Alp1 None 1
   II Alp1 IS1381-ISsAg4-GBSi1 1 (1)
   II Alp1 IS1381-ISsAg4 1
   III Alp3 IS1381-GBSi1 1
   VII Alp3 1S1381 2
   VII A IS1381 1
CC 10 (n = 16) CTAA Ib A IS1381-IS861 13
   II A IS1381-IS861-IS1548 1
   II A IS1381-IS861-ISsAg4 1
   V A IS1381-IS861 1
CC 17 (n = 7) CCGG III R IS861-GBSi1 6 (1)3
   Ia Alp1 IS1381 14
CC 19 (n = 50) CCAG III R IS1381-IS861-GBSi1 38 (4)5
   II R IS1381-IS861-IS1548 8
   V - GBSi1 1
   V Alp3 IS861-GBSi1 1 (1)
   V Alp3 GBSi1 1
CC 23 (n = 21) TCGG Ia Alp1 IS1381 16 (2)
   Ia Alp1 IS1381-IS861 1
   Ia Alp2 - 1
   V Alp1 IS1381-IS861 2
   II Alp2 - 1
New profile6 TCAG III R IS1381-IS861-IS1548 1
  1. 1For description of methods of identification of molecular serotype (MS), protein gene profiles (pgp) and mobile genetic elements (mge) see [5].
  2. 2SSI – sterile site isolates. Figures in brackets indicate the small subset of isolates from blood or CSF cultures from patients of varying ages. All others were from routine antenatal vaginal swabs or their sites of isolates were unknown (5 isolates). No attempt was made to identify differences between invasive and colonising isolates among those studied.
  3. 3The profile MS III-pgp R-mge IS861-GBSi1 is typical of the virulent serotype III subtype, which we have found previously to be associated with late onset neonatal sepsis) [6].
  4. 4This isolate was shown to not be CC17 by interrogation of the safety net SNP.
  5. 5The profile MSIII-pgp R-mge IS1381-IS861-GBSi1 is typical of the most common serotype III subtype, which is commonly found among vaginal isolates and is also a common cause of neonatal sepsis.
  6. 6This profile was derived from a mixed DNA sample and is likely an artefact.