Molecular typing of M. genitalium based on rRNA-SNPs. (A) SSCP analysis of a 246-bp DNA fragment covering the three polymorphic sites for types 2, 3 and 4 of the rRNA operon . The gel was sliver stained. (B) Distribution of M. genitalium rRNA-SNP genotypes between New Orleans (n = 44) and Scandinavia (n = 30) patients. The DNA sequences for types 2 to 5 are available from GenBank with accession numbers AY374418 to AY374421. By the generalized Fisher's exact test, p = 0.0004 for the overall distribution. By traditional Fisher's exact test, p = 0.0089 for type 2 and p = 0.0002 for type 3.