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Table 1 Efflux pumps promoting resistance to drugs described in E. coli*.

From: Predicting transcriptional regulatory interactions with artificial neural networks applied to E. coli multidrug resistance efflux pumps

(Super)Family

Efflux Components

Regulator(s)

Substrates

RND

AcrA, AcrB, TolC

AcrR, CRP, Fis, IHF, MarA, MarR, PhoP, Rob, SoxS, SdiA

AC, BL, BS, CM, CV, EB, FA, FQ, ML, NO, OS, RF, SDS, TX

 

AcrA, AcrD, TolC

BaeSR, EvgAS

AG, DC, FU, NO

 

AcrE, AcrF, TolC

AcrS, Fnr, ArcA

AC, BS, FQ, SDS, TX

 

MdtA, MdtBC, TolC

BaeSR

DC, NO

 

YhiU/MdtE, YhiV/MdtF, TolC

EvgAS, Ydeo

CV, DC, NO, SDS

MFS

EmrA, EmrB, TolC

EmrR

CCC, NA, TCS, TLM

 

EmrK, EmrY, TolC

Fnr, EvgAS, ArcA

CM, TC, SC

 

MdfA/Cmr

?

AG, CM, EB, EM, FQ, TC

ABC

YojI, TolC

?

MCJ

 

MdlAB

Rob

?

 

MsbA

?

EB, EM

 

MacA, MacB, TolC

?

EM

MATE

YdhE/NorM

?

AC, FQ, TPP

SMR

EmrE

?

AC, BK, CV, EB, EM, SF, TC, TPP

  1. For each pump was assigned the family, the set of acting proteins, the set of known regulators, and the toxic compounds extruded from the cell.
  2. * As provided in Kumar and Schweizer [16], UniProtKB/Swiss-Prot [47], Ecocyc Database [46] and RegulonDB [26]. Accessions date: Feb 2007.
  3. AC, acriflavine; AG, aminoglycosides; AP, amplicillin; BL, beta-lactams; BS, bile salts; BK, benzalkonium; CB, carbenicillin; CCC, carbonyl cyanide chlorophenylhydrazone; CH, cholate; CM, chloramphenicol; CO, coumestrol; CP, cephalosporins; CT, cefotaximine; CV, crystal violet; DC, deoxycholate; EB, ethidium bromide; EM, erythromycin; FA, fatty acids; FQ, fluoroquinolones; FU, fusidic acid; HL, homoserine lactones; MC, mitomycin; MCJ, microcin J25; ML, macrolides; NA, nalidixic acid; NO, novobiocin; OS, organic solvents; RD, rhodamine; RF, rifampicin; SC, salicylate; SDS, sodium dodecyl sulfate; SF, sulfadiazine; TC, tetracycline; TCS, tetrachlorosalicylanilide; TLM, thiolactomycin; TM, trimethoprim; TPP, tetraphenylphosphonium; TR, triclosan; TX, Triton X-100; ?, unknown or expressed constitutively.