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Table 1 Efflux pumps promoting resistance to drugs described in E. coli*.

From: Predicting transcriptional regulatory interactions with artificial neural networks applied to E. coli multidrug resistance efflux pumps

(Super)Family Efflux Components Regulator(s) Substrates
RND AcrA, AcrB, TolC AcrR, CRP, Fis, IHF, MarA, MarR, PhoP, Rob, SoxS, SdiA AC, BL, BS, CM, CV, EB, FA, FQ, ML, NO, OS, RF, SDS, TX
  AcrA, AcrD, TolC BaeSR, EvgAS AG, DC, FU, NO
  AcrE, AcrF, TolC AcrS, Fnr, ArcA AC, BS, FQ, SDS, TX
  MdtA, MdtBC, TolC BaeSR DC, NO
  YhiU/MdtE, YhiV/MdtF, TolC EvgAS, Ydeo CV, DC, NO, SDS
MFS EmrA, EmrB, TolC EmrR CCC, NA, TCS, TLM
  EmrK, EmrY, TolC Fnr, EvgAS, ArcA CM, TC, SC
  MdfA/Cmr ? AG, CM, EB, EM, FQ, TC
ABC YojI, TolC ? MCJ
  MdlAB Rob ?
  MsbA ? EB, EM
  MacA, MacB, TolC ? EM
MATE YdhE/NorM ? AC, FQ, TPP
SMR EmrE ? AC, BK, CV, EB, EM, SF, TC, TPP
  1. For each pump was assigned the family, the set of acting proteins, the set of known regulators, and the toxic compounds extruded from the cell.
  2. * As provided in Kumar and Schweizer [16], UniProtKB/Swiss-Prot [47], Ecocyc Database [46] and RegulonDB [26]. Accessions date: Feb 2007.
  3. AC, acriflavine; AG, aminoglycosides; AP, amplicillin; BL, beta-lactams; BS, bile salts; BK, benzalkonium; CB, carbenicillin; CCC, carbonyl cyanide chlorophenylhydrazone; CH, cholate; CM, chloramphenicol; CO, coumestrol; CP, cephalosporins; CT, cefotaximine; CV, crystal violet; DC, deoxycholate; EB, ethidium bromide; EM, erythromycin; FA, fatty acids; FQ, fluoroquinolones; FU, fusidic acid; HL, homoserine lactones; MC, mitomycin; MCJ, microcin J25; ML, macrolides; NA, nalidixic acid; NO, novobiocin; OS, organic solvents; RD, rhodamine; RF, rifampicin; SC, salicylate; SDS, sodium dodecyl sulfate; SF, sulfadiazine; TC, tetracycline; TCS, tetrachlorosalicylanilide; TLM, thiolactomycin; TM, trimethoprim; TPP, tetraphenylphosphonium; TR, triclosan; TX, Triton X-100; ?, unknown or expressed constitutively.