Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence

BMC Microbiology

Table 1 Regions of Diversity in S. pneumoniae and their function

Regions of Diversity^†	% GC content	Genes included in RD: TIGR annotation	Size (Kbp)	Encoded virulence determinants	Ref. cited
Characterized:
RD1	Typical	SP0067-75	10.0	ZmpC; zinc metalloproteinase C	10,11
RD3	Atypical	SP0346-360	16.4	capsular polysacharide synthesis operon	12
RD4	Typical	SP0641-649	18.5	RlrA pathogenicity islet	13–15
RD6	Highly Atypical	SP1028-1065	30.3	PPI1, pneumococcal pathogenicity island I	16–19
RD10	Highly Atypical	SP1755-1772	36.2	PsrP-secY2A2 pathogenicity island	8
Uncharacterized:
RD2	Typical	SP0163-171	6.3	n/a
RD5	Typical	SP0691-700	4.9	n/a
RD7	Atypical	SP1129-1147	10.6	n/a
RD8	Atypical	SP1315-1351	40.3	n/a
RD9	Typical	SP1612-1622	9.8	n/a
RD11	Atypical	SP1828-1831	3.7	n/a
RD12	Highly Atypical	SP1947-1957	11.1	n/a
RD13	Typical	SP2158-2166	10.9	n/a

ISSN: 1471-2180