Helicobacter pylori genome variability in a framework of familial transmission

BMC Microbiology

Table 4 Number of microarray divergent genes averaged by functional class and type of comparison

Functional category		Number of divergent genes for RAPD type A relative to type B isolates		Number of divergent genes for all isolates relative to the reference (26695/J99)
Code: Description	Number of genes	Mean ± SE¹	Percent	Mean ± SE¹	Percent
1–7, 9–12: Basic functions²	635	23 ± 1	4	42 ± 5	7
8: DNA metabolism	140	17 ± 1	12	44 ± 2	31
13: Cell envelope	165	11 ± 0.3	7	24 ± 1	15
14: Cellular processes	130	9 ± 0.4	7	18 ± 2	14
15: Plasmid- and transposon-related functions	9	5 ± 0.2	56	6 ± 0.3	67
16, 17: Unknown and hypothetical	666	82 ± 2	12	181 ± 7	27
All	1,745	147 ± 4	8	314 ± 16	18

Divergent genes were assessed by microarray for 15 H. pylori isolates, three isolates of RAPD type A (biopsy 15) and 12 isolates of RAPD type B (biopsy 16, 13, 125 and 24a). Divergent genes by functional class were identified for the type A isolates relative to the type B isolates and for all isolates relative to the reference strains.
¹Standard error
²1: Amino acid biosynthesis, 2: Purines, pyrimidines, nucleosides, and nucleotides, 3: Fatty acid and phospholipid metabolism, 4: Biosynthesis of cofactors, prosthetic groups and carriers, 5: Central intermediary metabolism, 6: Energy metabolism, 7: Transport and binding proteins, 9: Transcription, 10: Protein synthesis, 11: Protein fate, 12: Regulatory functions.

ISSN: 1471-2180