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Table 3 Candidate homologs for virulence factors induced in the cDNA transition library.

From: The transcriptome analysis of early morphogenesis in Paracoccidioides brasiliensis mycelium reveals novel and induced genes potentially associated to the dimorphic process

Virulence determinant Function in other fungi Reference number
Alpha -1,3 glucan synthase (ags1) Reduction of AGS1 activity reduces the lung colonization by Histoplasma capuslatum [40]
Glucanosyltransferase family protein (gel) Required for both morphogenesis and virulence in Aspergillus fumigatus [41]
Calcineurin subunit B (canB) Required for Candida albicans virulence and stress resistance [42]
Para-aminobenzoic acid synthetase (paba) Essential for Aspergillus fumigatus growth in lung tissue [43]
Peroxisomal catalase (cat P) Putatively related to the P. brasiliensis protection against peroxides [44]
Aspartyl protease (asp) Facilitation of pathogenesis in Candida albicans [45]
Zinc metalloprotease (mp) A elastolytic metalloprotease of Aspergillus fumigatus is secreted during fungal invasion of murine lung [46]
Phosholipase A2 (plaA) Gene inactivation attenuates virulence in Candida albicans [47]
Glyceraldehyde 3 phosphate dehydrogenase (gapdh) Recombinant GAPDH and antibodies to GAPDH diminish P. brasiliensis yeast binding to and infection of A549 pneumocytes [49]
Alpha-1,2 mannosyltransferase (mnn5) Important for virulence of Candida albicans [50]
Hemolysin like protein (hlp) Phase specific gene regulated by phenotypic switching in Candida glabrata [51]
Urease (ure) Required for Coccidioides posadasii virulence [52]