Table 3 Candidate homologs for virulence factors induced in the cDNA transition library.
Virulence determinant | Function in other fungi | Reference number |
|---|---|---|
Alpha -1,3 glucan synthase (ags1) | Reduction of AGS1 activity reduces the lung colonization by Histoplasma capuslatum | [40] |
Glucanosyltransferase family protein (gel) | Required for both morphogenesis and virulence in Aspergillus fumigatus | [41] |
Calcineurin subunit B (canB) | Required for Candida albicans virulence and stress resistance | [42] |
Para-aminobenzoic acid synthetase (paba) | Essential for Aspergillus fumigatus growth in lung tissue | [43] |
Peroxisomal catalase (cat P) | Putatively related to the P. brasiliensis protection against peroxides | [44] |
Aspartyl protease (asp) | Facilitation of pathogenesis in Candida albicans | [45] |
Zinc metalloprotease (mp) | A elastolytic metalloprotease of Aspergillus fumigatus is secreted during fungal invasion of murine lung | [46] |
Phosholipase A2 (plaA) | Gene inactivation attenuates virulence in Candida albicans | [47] |
Glyceraldehyde 3 phosphate dehydrogenase (gapdh) | Recombinant GAPDH and antibodies to GAPDH diminish P. brasiliensis yeast binding to and infection of A549 pneumocytes | [49] |
Alpha-1,2 mannosyltransferase (mnn5) | Important for virulence of Candida albicans | [50] |
Hemolysin like protein (hlp) | Phase specific gene regulated by phenotypic switching in Candida glabrata | [51] |
Urease (ure) | Required for Coccidioides posadasii virulence | [52] |