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Table 4 The number of positively selected sites in different functional domains of S protein.

From: Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups

Functional domain 02–04 interspecies epidemic group 03-early-mid epidemic group Fisher's exact test (p)
RBD 6 1  
HR1–HR2 1 4 0.045455
HR2 0 3 0.033333
  1. The Fisher's exact test was performed for HR1–HR2 vs. RBD, and HR2 vs. RBD, respectively.