Figure 1

Proposed RND efflux pump encoded by B. cenocepacia genome. The organization of the RND efflux pump genes identified in B. cenocepacia genome was achieved by bioinformatic tools as described in Methods. RND transporter-encoding genes are depicted as grey arrows (orf1–orf14), outer-membrane factor-encoding genes as white arrows, periplasmic membrane fusion protein-encoding genes as black arrows, and regulatory genes as arrows with stripes. Black lines indicate the regions of Stress-Induced DNA duplex Destabilization that could be associated with promoters. Genes encoding protein components of CeoAB-OpcM (6) are indicated as white arrow (opcM), grey arrow (ceoB), black arrow (ceoA); arrows with stripes and squares indicated the ceoR and llpE genes encoding a regulator and a putative periplasmic lipase-like protein, respectively.