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Table 2 Stratified analysis: effect of study and test characteristics on summary diagnostic odds ratios

From: In-house nucleic acid amplification tests for the detection of Mycobacterium tuberculosis in sputum specimens: meta-analysis and meta-regression

Subgroup (Number of studies)   Summary DOR (95% CI)
Study design Case-control (24) 134.4 (65.2 – 213.1)
  Cross-sectional (60) 171.1 (106.7 – 274.2)
Blinding Single or double blinded (29) 90.2 (46.2 – 176.2)
  Unblinded or NR (55) 221.2 (137.7 – 355.2)
DNA extraction method Chemical (55) 153.7 (90.1 – 262.4)
  Physical (29) 171.7 (96.2 – 306.6)
Amplification method PCR/multiplex (68) 139.3 (89.2 – 217.7)
  Nested PCR (16) 266.6 (140.8 – 504.6)
Target sequence IS6110 (54) 236.1 (152.9 – 364.6)
  Other target (30) 77.4 (38.2 – 156.9)
Detection method Probe (49) 130.6 (78.4 – 217.6)
  Gel-UV (35) 215.4 (115.1 – 403.2)
Sputum smear status Pos/Both/NR (78) 161.5 (107.5 – 242.6)
  Negative (6) 128.6 (33.4 – 495.1)