Table 2 Stratified analysis: effect of study and test characteristics on summary diagnostic odds ratios
Subgroup (Number of studies) | Â | Summary DOR (95% CI) |
|---|---|---|
Study design | Case-control (24) | 134.4 (65.2 – 213.1) |
|  | Cross-sectional (60) | 171.1 (106.7 – 274.2) |
Blinding | Single or double blinded (29) | 90.2 (46.2 – 176.2) |
|  | Unblinded or NR (55) | 221.2 (137.7 – 355.2) |
DNA extraction method | Chemical (55) | 153.7 (90.1 – 262.4) |
|  | Physical (29) | 171.7 (96.2 – 306.6) |
Amplification method | PCR/multiplex (68) | 139.3 (89.2 – 217.7) |
|  | Nested PCR (16) | 266.6 (140.8 – 504.6) |
Target sequence | IS6110 (54) | 236.1 (152.9 – 364.6) |
|  | Other target (30) | 77.4 (38.2 – 156.9) |
Detection method | Probe (49) | 130.6 (78.4 – 217.6) |
|  | Gel-UV (35) | 215.4 (115.1 – 403.2) |
Sputum smear status | Pos/Both/NR (78) | 161.5 (107.5 – 242.6) |
|  | Negative (6) | 128.6 (33.4 – 495.1) |