Skip to main content

Table 1 Study characteristics and methodological quality of included studies

From: In-house nucleic acid amplification tests for the detection of Mycobacterium tuberculosis in sputum specimens: meta-analysis and meta-regression

Study characteristic Frequency [N = 84 studies]
Study design  
   Cross sectional 60 (71%)
   Case-control 24 (29%)
Blinded assessment of NAA test and reference standard results  
   Double or single blinded 29 (34%)
   Unblinded or Unknown 55 (66%)
Target sequence for amplification  
   IS6110 54 (64%)
   Other target sequences 30 (36%)
Use of chemical-based DNA extraction method  
   Any chemical method 55 (66%)
   Physical methods 29 (34%)
Amplification technique  
   Nested or semi-nested PCR 16 (19%)
   Regular or multi-plex PCR 68 (81%)
Detection of amplified products  
   Probe-based method 49 (58%)
   Gel-UV method 35 (42%)