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Table 2 Predicted DtxR-binding sites in C. diphtheriae

From: Prediction of DtxR regulon: Identification of binding sites and operons controlled by Diphtheria toxin repressor in Corynebacterium diphtheriae

Score Position Site Gene Synonym Product
4.45904 -80 TGAGGGGAACCTAACCTAA hmuO DIP1669** heme oxygenase
4.39003 -52 TTAGGATAGCTTTACCTAA Tox DIP0222** Diphtheria toxin precursor
4.25877 -60 ATAGGCTACACTTACCTAA - DIP0624 Putative membrane protein
4.21068 -168 TTGGATTAGCCTACCCTAA - DIP2162** ABC-type peptide transport system periplasmic component
4.2033 -21 TTAGGGTAGCTTCGCCTAA iucA DIP0586 Putative siderophore biosynthesis related protein
4.17632 -78 ATAGGCATGCCTAACCTCA - DIP2330 Putative membrane protein
4.07921 -130 TTAGGTCAGGGTACCCTAA - DIP0370 Putative succinate dehydrogenease cytochrome B subunit
4.03559 -30 TTAGCTTAACCTTGCCTAT arsR DIP0415 Putative ArsR family regulatory protein
4.01967 -239 TTAGGGTAGGCTAATCCAA sidA* DIP2161 nonribosomal peptide synthase
3.99985 -74 TTTTCTTTGCCTAGCCTAA irp6A DIP0108** Ferrisiderophore receptor Irp6A
3.99195 -241 TTAGGCACCCCTAACCTAG - DIP0539 Putative sugar ABC transport syste ATP-binding protein
3.98554 -72 TTAGCTTAGCCCTAGCTAA - DIP0169 Putative secreted protein
3.9296 -26 CTAGGATTGCCTACACTTA Irp5 DIP0894** Conserved hypothetical protein
3.9073 -93 GTTGGGTTGCCCAACCTAC - DIP2106 Putative ABC transport system, ATP-binding subunit
3.89763 -86 ATAGGTTAGGTTAACCTTG chtA* DIP1520 Putative membrane protein
3.89676 -130 TTGTGTTAGCCTAGGCTAA secA DIP0699 Translocase protein
3.89169 -26 TTGGGGTGGCCTATCCTTA - DIP2304 Putative DNA-repair glycosylase
3.88042 -172 TTAGGTAAGTGTAGCCTAT htaA* DIP0625 Putative membrane protein
3.86534 -69 ATTACTAATGCTAACCTAA Irp4 DIP2356** Putative conserved membrane protein
3.85539 -173 TTAGGGTGGGCTAACCTGC deoR* DIP1296 Putative DNA-binding protein
3.84889 -75 TTAGGGAACTCTTGCCTTA piuB* DIP0124 Putative membrane protein
3.83816 -121 TTAGCTAGGGCTAAGCTAA - DIP0168 Putative glycosyl transferase
3.83576 -219 GTAACAAAGGCAAGCCTAA xerD DIP1510 Putative integrase/recombinase
3.8224 -216 ATAGGCAAGGTTAAGCTAA - DIP0417 Putative membrane protein
3.81905 -47 GTTGGACAGGTTACCCTAA frgA* DIP1061 Putative iron-siderophore uptake system permease
3.8148 -37 TGTGGGCACACCAACCTAA - DIP2272 possible sortase-like protein
3.76235 -136 TTGGGGTTGCCCTTCCTAA - DIP0142 Hypothetical protein
3.76233 -268 CTAGGTTAGGGGTGCCTAA secY* DIP0540 preprotein translocase SecY subunit
3.74673 -110 TAAACATAGCCAAACCAAA nrdF1 DIP1865 ribonucleotide reductase beta-chain 1
3.7438 -81 TAAGGATAGGCCACCCCAA Dps DIP2303 Starvation inducible DNA-binding protein
  1. Note: **Indicate the gene synonym with experimentally identified binding site in C. diphtheriae [6]. * Indicates the genes known to be regulated by DtxR [7]. The binding sites in Italics were verified by EMSA. The gene pairs, DIP0624-DIP0625, DIP2161-DIP2162, DIP0168-DIP0169, DIP0539-DIP0540 and DIP2303-DIP2304 are divergently transcribed and contain common regulatory regions.