From: Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis
Inhibitor | Inhibition (%) | Inhibitor | Inhibition (%) |
---|---|---|---|
8-Chlorotheophylline | 7.0 ± 4.1 | 1,3,7-Trimethyluric acid | 0.0 ± 0.0 |
7-Hydroxypropyl theophylline | 16.1 ± 4.0 | 6-Bromopurine | 31.4 ± 1.5 |
Uric acid | 45.6 ± 11.9 | 7-Methylxanthine | 36.3 ± 4.2 |
Xanthine | 35.4 ± 2.5 | 1-Methylxanthine | 35.9 ± 5.8 |
8-Azaguanine | 81.7 ± 2.8 | 2-Hydroxypurine | 33.8 ± 0.6 |
3,7-Dimethyluric acid | 27.9 ± 1.6 | 6-Chloropurine | 31.4 ± 7.3 |
2,6-Dichloropurine | 35.5 ± 6.9 | 2-Amino-6-chloropurine-9-acetic acid | 23.5 ± 8.4 |
6-Mercaptopurine | 40.1 ± 2.3 | 6-Benzyloxypurine | 17.7 ± 3.4 |
1-Methyluric acid | 43.4 ± 2.9 | 2-Aminopurine | 11.0 ± 2.1 |
Purine riboside | 44.4 ± 5.9 | 6-Methylpurine | 0.0 ± 0.0 |
O-Methylguanine | 60.3 ± 5.3 | 7-Methyluric acid | 11.4 ± 2.2 |
2,6-Diaminopurine | 29.3 ± 7.9 | 6-Cyanopurine | 24.2 ± 4.6 |
2-Amino-6-carboxy ethyl mercaptopurine | 31.9 ± 9.8 | 2-Amino-6-chloropurine riboside | 17.2 ± 3.3 |
6-Propoxypurine | 27.9 ± 4.0 | 6-Dimethyl aminopurine | 28.0 ± 5.3 |
6-Dimethylallyl aminopurine riboside | 41.6 ± 5.5 | Azathioprine | 75.5 ± 5.4 |
8-Aza-2,6-diaminopurine | 40.0 ± 2.2 | 6-Mercaptopurine riboside | 30.0 ± 5.7 |
6-Chloropurine riboside | 17.1 ± 3.5 |  |  |