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Figure 6 | BMC Microbiology

Figure 6

From: Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages

Figure 6

Degradation of 125I-fibrinogen by M. tuberculosis culture filtrates and inhibition by class-specific protease inhibitors. Culture filtrates were concentrated 20-fold and incubated with 125I-fibrinogen for 16 h. Class specific protease inhibitors (defined in the text) were added to the protease assays, which were performed as described in the Methods. Extent of 125I-fibrinogen degradation was quantified by measurement of TCA-soluble counts. Results are expressed as percent degradation relative to control (no inhibitor) and are the means ± standard deviations of four independent experiments.

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