Table 2 Genes differentially expressed in H. influenzae Eagan at pHÂ 8.0 compared to pHÂ 6.8
Genes up-regulated at pHÂ 8.0 compared to 6.8 | ||||
|---|---|---|---|---|
Metabolic genes | ||||
Gene | Log 2 fold | p -values | FDR | Comment |
HI1010 | 2.21 | 5.12×10-10 | 1.02×10-7 | 6-phosphogluconate dehydrogenase |
HI1011 | 2.20 | 6.83×10-10 | 1.22x10-7 | Similar to YgbK |
HI1012 | 2.04 | 3.06×10-8 | 3.64x10-6 | Sugar isomerase |
HI1013 | 1.88 | 3.04×10-7 | 2.86×10-5 | Hydroxypyruvate isomerase |
HI1014 | 1.52 | 2.33×10-5 | 1.54×10-3 | Sugar epimerase |
HI1015 | 1.12 | 1.18×10-3 | 4.70×10-2 | GntP family, gluconate:H+ symporter |
HI0091 | 1.74 | 5.98×10-7 | 5.33×10-5 | Hypothetical protein; homologous to GlxK, glycerate kinase |
HI0092 | 2.14 | 1.49×10-9 | 2.41×10-7 | GntP family, gluconate:H+ symporter |
Iron uptake genes | ||||
Gene | Log 2 fold | p -value | FDR | Comment |
HI0995 | 1.53 | 1.72×10-5 | 1.23×10-3 | OMP, iron-binding |
hitA | 2.21 | 1.69×10-10 | 3.77×10-8 | Iron uptake |
hxuB | 1.65 | 1.54×10-6 | 1.25×10-4 | Hemopexin utilization protein |
hxuC | 1.70 | 8.04×10-7 | 6.83×10-5 | TonB-dependent heme receptor |
Genes of unknown function | ||||
Gene | Log 2 fold | p -value | FDR | Comment |
HI1427 | 1.54 | 6.87×10-6 | 5.33×10-4 | Hypothetical protein |
Genes down-regulated at pHÂ 8.0 compared to 6.8 | ||||
Gene | Log 2 fold | p -value | FDR | Comment |
HI1349 | -2.31 | 5.58×10-11 | 1.42×10-8 | Ferritin |
HI1385 | -1.55 | 2.27×10-5 | 1.54×10-3 | FtnB; non-heme ferritin |