Resistance genotypesa
|
PBP3 typesb
|
n
c
|
Sgd
|
Blae
|
PBP3 substitutionsf
|
---|
D
|
S
|
A
|
M
|
S
|
P
|
A
|
I
|
G
|
A
|
V
|
R
|
N
|
A
|
T
|
V
|
D
|
A
|
N
|
---|
350
|
357
|
368
|
377
|
385
|
392
|
437
|
449
|
490
|
502
|
511
|
517
|
526
|
530
|
532
|
547
|
551
|
554
|
569
|
---|
High-rPBP3
| | | | | | | | | | | | | | | | | | | | | |
Group III
|
-
|
1
| | |
N
|
N
| | |
T
| | | | |
T
| | |
K
g
| | |
I
| | |
S
|
Group III-like
|
-
|
2
| | |
N
|
N
| |
I
|
T
| | | | | | |
H
| | |
S
|
I
| | | |
Low-rPBP3
| | | | | | | | | | | | | | | | | | | | | |
Group II
|
A
|
48
| |
1
|
N
| | |
I
| | | | | |
V
| | |
K
h
| | |
I
| | |
S
|
|
B
|
19
| |
5
| | | | | | | |
V
| | | | |
K
g
| | |
I
| | |
S
|
|
C
|
5
| | |
N
| | |
I
| | | | |
E
| | | |
K
h
| | |
I
| | |
S
|
|
D
|
17
| | |
N
| | | | | | | |
E
| | | |
K
g
|
S
| | | | | |
|
F
|
1
| | | | | | | | | | | | | | |
K
g
| | | | | | |
|
H
|
6
| | | | | | | | | | | |
V
| | |
K
h
| | | | | | |
|
I
|
4
| | |
N
| | | | | |
S
| | |
V
| | |
K
g
| | |
I
| | |
S
|
|
J
|
3
| | |
N
| | | | | | | | |
T
| | |
K
g
| | |
I
| | |
S
|
|
K
|
2
| | | | |
T
| | | | | | |
T
| | |
K
g
| | | | | | |
|
L
|
1
| | |
N
| | | | | | | |
E
| | | |
K
g
| | |
I
| |
Di
|
S
|
|
M
|
1
| | |
N
| | | | | | | | |
V
| | |
K
h
| | |
I
| | |
S
|
|
N
|
1
| |
1
|
N
| | | | | |
S
|
V
| | | | |
K
g
| | |
I
| | |
S
|
|
O
|
1
| | | | | | | | | | | |
T
| | |
K
g
| | |
I
| | |
S
|
|
P
|
1
| | | | | | | | | | | |
T
| | |
K
g
| | |
I
| | | |
|
Q
|
1
| | | | | | | | | | |
E
|
V
| | |
K
h
| | |
I
| | |
S
|
Group I
|
-
|
2
| | | | | | | | | | | | | |
H
| | | |
I
| |
T
| |
sPBP3
|
z0
|
51
|
15
|
6
| | | | | | | | | | | | | | | | | | | |
z4
|
9
|
1
| |
N
| | | | | | | | | | | | | | |
I
| | |
S
|
z1
|
7
|
3
|
2
| | | | | | | | | | | | | | | |
I
| | | |
z6
|
3
| | | | | | | | | | | | | | | | | |
I
| | |
S
|
z7
|
3
| | | | | | | | | | | | | | | | | |
I
| |
T
|
S
|
z5
|
1
| |
1
| | | | | | | | | |
S
| | | | | | | | | |
z8
|
1
| | |
N
| | | | | | | | |
T
| | | | | |
I
| | |
S
|
z9
|
1
| | |
N
| | | | | | | | | | | | | | |
I
| | | |
z10
|
1
| | | | | | | | | | | | | | | | | |
I
|
Ai
| | |
z11
|
1
| | | | | | | | | | | | |
A
| | | | |
I
| | | |
z12
|
1
| | | | | | | |
Si
| | | | | | | | | | | | | |
z13
|
1
| | | | | | | | | | | |
T
| | | | | | | | | |
-
aSee Table 1.
-
bPBP3 types according to Skaare et al.[11] (types A – G) and this study (types H – Q and z0 – z13). ‘-‘, not designated.
-
c
n, No. of study isolates.
-
dSg, No. of isolates from the Susceptible group included in n.
-
eBla, No. of beta-lactamase positive isolates (all TEM-1) included in n.
-
fAmino acid substitutions in PBP3 (transpeptidase domain, 338–573) with the amino acid sequence of H. influenzae Rd KW20 [GenBank:U32793] as reference (z0). Essential substitutions in bold.
-
gN526K encoded by the DNA triplet AAG.
-
hN526K encoded by the DNA triplet AAA.
-
iNovel substitution.