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Table 1 Occurrence of virulence factors in E. coli pathotypes

From: Bacteriocin-encoding genes and ExPEC virulence determinants are associated in human fecal Escherichia coli strains

Virulence factors

Pathotype

 

Non-pathogenic E. coli*

Diarrhea-associated E. coli**

ExPEC***

 

n = 399 (%)

n = 179 (%)

n = 603 (%)

Aggregative adherence plasmid

pCVD432

-

13 (7.3)

-

Invasive associated locus

ial

-

44 (24.6)

-

Heat-stable enterotoxin

st

-

8 (4.5)

-

Heat-labile enterotoxin

lt

-

7 (3.9)

-

Intimin

eaeA

-

26 (14.5)

-

Bundle-forming fimbriae

bfpA

-

1 (0.6)

-

Invasion plasmid H

ipaH

-

19 (10.6)

-

Aerobactin synthesis

aer

-

68 (38.0)

342 (56.7)

Fimbriae type 1

fimA

336 (84.2)

149 (83.2)

553 (91.7)

α-hemolysin

α-hly

-

3 (1.7)

88 (14.6)

Afimbrial adhesin

afaI

-

78 (43.6)

-

Aerobactin synthesis

iucC

-

80 (44.7)

396 (65.7)

Cytotoxic necrotizing factor

cnf1

-

1 (0.6)

43 (7.1)

S-fimbriae

sfa

-

6 (3.4)

227 (37.6)

P-fimbriae

pap

-

19 (10.6)

201 (33.3)

Shiga-toxin 1

stx1

-

-

-

Shiga-toxin 2

stx2

-

-

-

Enterohemolysin

ehly

-

9 (5.0)

-

  1. *E. coli strains with no detected genes for virulence factors or those possessing only gene for fimbriae type I (fimA gene).
  2. **EAggEC - pCVD432 (aggregative adherence plasmid); ETEC - lt/st (heat-labile and heat-stable enterotoxin); EIEC - ial/ipaH (invasion associated locus/invasion plasmid H); EPEC – bfpA/eaeA (bundle-forming fimbriae/intimin); EHEC (stx1/stx2/ehly); DAEC – afaI (afimbrial adhesin I).
  3. ***E. coli strains which contain different virulence factors (except those that are typical for previously described diarrhea-associated E. coli) typical for extraintestinal E. coli strains (α-hemolysin, P-fimbriae, S-fimbriae, cytotoxic necrosis factor, aerobactin synthesis).