Table 5 A. fumigatus secondary metabolite biosynthetic gene clusters determined by SMURF, antiSMASH and by manual annotation or experimental characterization
A. fumigatuscluster summary | |||||||
|---|---|---|---|---|---|---|---|
| Â | Backbone enzyme | SMURF | antiSMASH | Manual/experimental | Boundary 1 | Boundary 2 | Reference |
Fumigaclavine C (fga) cluster* | Afu2g18040 | Afu2g17930 - Afu2g18070 | Afu2g17950 - Afu2g18070 | Afu2g17960 - Afu2g18060 | ED | ED | [48] |
Fumitremorgin B (ftm) cluster* | Afu8g00210 | Afu8g00280 - Afu8g00100 | Afu8g00100 - Afu8g00110 | Afu8g00260 - Afu8g00170 | ED | ED | [49] |
Gliotoxin (gli) cluster* | Afu6g09650 | Afu6g09580 - Afu6g09740 | Afu6g09520 - Afu6g09745 | Afu6g09630 - Afu6g09740 | ED, IGD | ED | [50] |
Pseurotin A cluster* | Afu8g00540 | - | Afu8g00342 - Afu8g00595 | Afu8g005340 - Afu8g00570 | ED | ED | [35] |
Siderophore (sid) cluster* | Afu3g03420 | Afu3g03280 - Afu3g03580 | Afu3g03270 - Afu3g03490 | Afu3g03300 - Afu3g03460 | ED | ED | [48] |
Afu1g01010 cluster | Afu1g01010 | Afu1g00970 - Afu1g01010 | Afu1g00970 - Afu1g01030 | Afu1g00980 - Afu1g01010 | FA | IGD | This study |
Afu1g10380 (nrps1) cluster | Afu1g10380 | Afu1g10310 - Afu1g10380 | Afu1g10310 - Afu1g10420 | Afu1g10270 - Afu1g10380 | ECS | IGD | This study |
Afu1g17200 (sidC) cluster | Afu1g17200 | Afu1g17080 - Afu1g17240 | Afu1g17090 - Afu1g17270 | Afu1g17200 - Afu1g17240 | ECS | ECS | This study |
Afu1g17740 cluster | Afu1g17740 | Afu1g17710 - Afu1g17740 | Afu1g17720 - Afu1g17750 | Afu1g17710 - Afu1g17740 | ECS | ECS | This study |
Afu2g01290 cluster | Afu2g01290 | Afu2g01170 - Afu2g01400 | Afu2g01210 - Afu2g01390 | Afu2g01280 - Afu2g01330 | ECS | ECS | This study |
Afu2g05760 cluster | Afu2g05760 | Afu2g05730 - Afu2g05840 | - | Afu2g05740 - Afu2g05830 | IGD | IGD | This study |
Afu2g17600 cluster | Afu2g17600 | Afu2g17511 - Afu2g17600 | Afu2g17490 - Afu2g17690 | Afu2g17480 - Afu2g17600 | IGD | IGD | This study |
Afu3g01410 cluster | Afu3g01410 | Afu3g01400 - Afu3g01560 | Afu3g01360 - Afu3g01560 | Afu3g01400 - Afu3g01480 | IGD | IGD | This study |
Afu3g02530 cluster | Afu3g02530 | Afu3g02450 - Afu3g02540 | Afu3g02450 - Afu3g02650 | Afu3g02520 - Afu3g02650 | FA | IGD | This study |
Afu3g02570 cluster | Afu3g02570 | Afu3g02570 - Afu3g02650 | Afu3g02450 - Afu3g02650 | Afu3g02520 - Afu3g02650 | FA | IGD | This study |
Afu3g02670 cluster | Afu3g02670 | Afu3g02670 - Afu3g02760 | Afu3g02670 - Afu3g02760 | Afu3g02670 - Afu3g02720 | ECS, IGD | ECS, IGD | This study |
Afu3g12920 cluster | Afu3g12920 | Afu3g12960 - Afu3g12750 | Afu3g13020 - Afu3g12820 | Afu3g12960 - Afu3g12890 | ECS | ECS | This study |
Afu3g12930 cluster | Afu3g12930 | Afu3g13000 - Afu3g12750 | Afu3g13020 - Afu3g12820 | Afu3g12960 - Afu3g12890 | ECS | ECS | This study |
Afu3g13730 cluster | Afu3g13730 | Afu3g13730 - Afu3g13600 | Afu3g13790 - Afu3g13600 | Afu3g13750 - Afu3g13670 | IGD | FA | This study |
Afu3g14700 cluster | Afu3g14700 | Afu3g14880 - Afu3g14690 | Afu3g14820 - Afu3g14620 | Afu3g14730 - Afu3g14690 | ECS | FA | This study |
Afu3g15270 cluster | Afu3g15270 | Afu3g15290 - Afu3g15250 | Afu3g15350 - Afu3g15190 | Afu3g15290 - Afu3g15240 | ECS, IGD | ECS | This study |
Afu4g00210 cluster | Afu4g00210 | Afu4g00260 - Afu4g00210 | Afu4g00290 - Afu4g00150 | Afu4g00260 - Afu4g00200 | IGD | ECS | This study |
Afu4g14560 cluster | Afu4g14560 | Afu4g14730 - Afu4g14420 | Afu4g14660 - Afu4g14440 | Afu4g14610 - Afu4g14450 | ECS | ECS | This study |
Afu5g10120 cluster | Afu5g10120 | Afu5g10250 - Afu5g09970 | Afu5g10240 - Afu5g10010 | Afu5g10130 - Afu5g10040 | ECS | FA | This study |
Afu5g12730 cluster | Afu5g12730 | Afu5g12840 - Afu5g12720 | Afu5g12830 - Afu5g12680 | Afu5g12770 - Afu5g12730 | FA | ECS | This study |
Afu6g03480 cluster | Afu6g03480 | Afu6g03620 - Afu6g03430 | Afu6g03550 - Afu6g03400 | Afu6g03490 - Afu6g03430 | ECS | ECS, IGD | This study |
Afu6g08560 cluster | Afu6g08560 | Afu6g08540 - Afu6g08560 | Afu6g08520 - Afu6g08640 | Afu6g08550 - Afu6g08560 | ECS | ECS | ECS, IGD |
Afu6g12080 cluster | Afu6g12080 | Afu6g12040 - Afu6g12160 | Afu6g11980 - Afu6g12145 | Afu6g12040 - Afu6g12080 | ECS | ECS | This study |
Afu6g13930 cluster | Afu6g13930 | Afu6g13830 - Afu6g14050 | Afu6g13820 - Afu6g14030 | Afu6g13920 - Afu6g14000 | ECS | ECS | This study |
Afu7g00170 cluster | Afu7g00170 | Afu7g00200 - Afu7g00120 | Afu7g00220 - Afu7g00100 | Afu7g00190 - Afu7g00120 | ECS | ECS, IGD | This study |
Afu8g00540 cluster | Afu8g00540 | Afu8g00370 - Afu8g00370 | Afu8g00490 - Afu8g00310 | - | n/a | n/a | This study |
Afu8g00620 cluster | Afu8g00620 | Afu8g00640 - Afu8g00470 | Afu8g00720 - Afu8g00390 | - | n/a | n/a | This study |
Afu8g01640 cluster | Afu8g01640 | Afu8g01640 - Afu8g01640 | Afu8g01600 - Afu8g01730 | Afu8g01630 - Afu8g01640 | ECS, IGD | ECS, IGD | This study |
Afu8g02350 cluster | Afu8g02350 | Afu8g02460 - Afu8g02350 | Afu8g02490 - Afu8g02280 | Afu8g02430 - Afu8g02350 | ECS, IGD | ECS, IGD | This study |
No PKS or NRPS backbone 1 | n/a | - | Afu4g11170 - Afu4g11300 | - | n/a | n/a | Â |
No PKS or NRPS backbone 2 | n/a | - | Afu4g11980 - Afu4g12070 | - | n/a | n/a | Â |
No PKS or NRPS backbone 3 | n/a | - | Afu5g00100 - Afu5g04130 | - | n/a | n/a | Â |
No PKS or NRPS backbone 4 | n/a | - | Afu7g00230 -Afu7g00350 | Afu5g00100 - Afu5g00135 | ECS, IGD | ECS, IGD | This study |
No PKS or NRPS backbone 5 | n/a | - | Afu7g01180 - Afu7g01270 | Afu7g00260 - Afu7g00270 | ECS, FA | ECS | This study |