Table 1 Annotated ESTs up and down regulated genes of Paracoccidioides yeast cells treated with OenB by 90 and 180Â min
Functional category | Gene product | Paracoccidioidesacession numbera | e-value | Number of occurrence | |
|---|---|---|---|---|---|
90Â min | 180Â min | ||||
Metabolism | |||||
    Amino acids metabolism | Alanine glyoxylate aminotransferase (AGX1) | PAAG_03138.1 | 1e-152 | +2 | -1 |
Hexokinase 1 (HXK1) | PAAG_01377.1 | 2e-48 | +2 | Â | |
Urease (URE) | PAAG_00954.1 | 0.0 | +1 | Â | |
    Carbohydrate metabolism | Betaine aldehyde dehydrogenase (BADH) | PAAG_05392.1 | 0.0 | -13 | -16 |
β glucosidase (BGLU) | PAAG_04545.1 | 0.0 | +1 |  | |
Cysteine desulfurase (NFS1) | PAAG_05850.1 | 2e-122 | +4 | -7 | |
Trehalose phosphatase (TPS1) | PAAG_06703.1 | 1e-165 | +20 | Â | |
    Fatty acid metabolism | C-5 sterol desaturase (ERG 3) | PAAG_03651.1 | 1e-166 | -4 |  |
NADP-dependent leukotriene B4 12-hydroxydrogenase (LTB 4 DH) | PAAG_05416.1 | 5e-179 | +1 | Â | |
Fatty acid elongase (GNS1/SUR4) | PAAG_08553.1 | 0.0 | +2 | Â | |
    Polysaccharide biosynthesis | Glutamine synthetase (GLN1) | PAAG_07003.1 | 0.0 | +11 | +1 |
Energy | |||||
    Fatty acid β-oxidation | Acyl-CoA dehydrogenase (ACAD) | PAAG_03490.1 | 2e-85 | +1 |  |
    Energy generation | Glucose methanol choline oxidorreductase (GMCO) | PAAG_08146.1 | 0.0 |  | +3 |
Morphology | β glucan synthesis associated protein (KRE6) | PAAG_00091.1 | 2e-36 |  | +3 |
α 1,6 mannosyltransferase (OCH1) | PAAG_01658.1 | 0.0 | +5 |  | |
Arp 2/3 complex subunit Arc16 | PAAG_03624.1 | 0.0 | Â | +12 | |
Cell morphology protein (PAL1) | PAAG_02031.1 | 0.0 | +1 | Â | |
Integral membrane protein (MPV17/PMP22) | PAAG_02868.1 | 4e-87 | -6 | Â | |
GYF domain protein | PAAG_00627.1 | 0.0 | +5 | Â | |
Transcription | C2H2 transcription factor (SEB1) | PAAG_03287.1 | 0.0 | +2 | Â |
C6 transcription factor (CTF1B) | PAAG_01359.1 | 0.0 | -15 | +54 | |
Fork head box protein D1 (FOXD1) | PAAG_07388.1 | 4e-40 | +1 | Â | |
GATA type sexual (NSDD) | PAAG_05818.1 | 3e-127 | +22 | -4 | |
Histone deacetylase (RPD3) | PAAG_06742.1 | 0.0 | +12 | Â | |
RING finger protein (RNF) | PAAG_06129.1 | 0.0 | -3 | -15 | |
Transcription factor (ATF1) | PAAG_01945.1 | 5e-169 | +1 | Â | |
Transcription factor fungi | PAAG_02049.1 | 0.0 | Â | +65 | |
Protein RNP domain | PAAG_03136.1 | 6e-98 | +2 | Â | |
Transcription factor prr1(HSF1) | PAAG_05064.1 | 6e-89 | +1 | Â | |
Transcription factor (STEA) | PAAG_00406.1 | 0.0 | +18 | Â | |
Signal transducer | Guanine nucleotide binding protein alpha-1 subunit (GPA2) | PAAG_04436.1 | 5e-178 | -23 | Â |
Protein with PYP-likesensor domain (PAS) | PAAG_06301.1 | 0.0 | +10 | -44 | |
Protein fate | Proteasome component (PRE6) | PAAG_07802.1 | 7e-70 | Â | +3 |
Protein synthesis | Elongation factor 1-gamma 1 (eEF-1) | PAAG_03556.1 | 0.0 | Â | -1 |
ATP-dependent RNA helicase (eIF-4A) | PAAG_00689.1 | 0.0 | +2 | -9 | |
Cellular transport, transport facilities and transport routes | Calcium-transporting ATPase sarcoplasmic/endoplamic reticulum type (PMR1) | PAAG_00774.1 | 0.0 | +1 | Â |
Ferric-chelate reductase (FRE) | PAAG_05370.1 | 7e-107 | Â | +2 | |
Succinate/fumarate mitochondrial transporter (SFC1) | PAAG_06563.1 | 0.0 | -4 | Â | |
Membrane biogenesis protein (YOP1) | PAAG_00481.1 | 7e-143 | Â | +1 | |
Major facilitator superfamily transporter (MFS) | PAAG_01353.1 | 0.0 | -27 | -22 | |
Bodown 198 – Major facilitador superfamily transporter | PAAG_06077.1 | 3e-124 | -4 |  | |
Cell cycle and DNA processing | Ribonuclease reductase large subunit (RNR1) | PAAG_02210.1 | 5e-175 | +1 | Â |
Arginine N-methyltransferase - SKB1 (PRMT5) | PAAG_02402.1 | 0.0 | +52 | Â | |
SH3 domain-containing protein (CYK3) | PAAG_02301.1 | 0.0 | +2 | Â | |
Cell rescue, defense and virulence | |||||
    Stress Response | Phosphatase regulatory subunit (GAC1) | PAAG_00128.1 | 0.0 | +10 |  |
Heat shock protein (HSP70) | PAAG_08003.1 | 1e-74 | -1 | Â | |
    Virulence factor | Pathogenesis associated protein (CAP20) | PAAG_06538.1 | 0.0 |  | -21 |
Functional unclassified proteins | Uncharacterized protein family UPF0121 | PAAG_00184.1 | 9e-94 | Â | +4 |
Pleckstrin Homology (PH) domain | PAAG_03092.1 | 0.0 | +11 | Â | |
DUF 1688 domain protein | PAAG_04190.1 | 0.0 | +154 | Â | |
Unclassified proteins | Conserved hypothetical protein | PAAG_06834.1 | 0.0 | +25 | Â |
Conserved hypothetical protein | PAAG_07365.1 | 0.0 | +34 | Â | |
Conserved hypothetical protein | PAAG_05009.1 | 0.0 | +10 | -3 | |
Conserved hypothetical protein | PAAG_07364.1 | 2e-139 | +4 | +2 | |
Conserved hypothetical protein | PAAG_04732.1 | 0.0 | +7 | Â | |
Conserved hypothetical protein | PAAG_03559.1 | 0.0 | +2 | Â | |
Conserved hypothetical protein | PAAG_02868.1 | 4e-87 | +11 | Â | |
Conserved hypothetical protein | PAAG_01170.1 | 9e-122 | +1 | Â | |
Conserved hypothetical protein | PAAG_04190.1 | 0.0 | -1 | Â | |
Conserved hypothetical protein | PAAG_06925.1 | 0.0 | Â | +1 | |
Conserved hypothetical protein | PAAG_08832.1 | 3e-143 | Â | +5 | |
Conserved hypothetical protein | PAAG_07770.1 | 3e-143 | Â | +1 | |
Conserved hypothetical protein | PAAG_03654.1 | 2e-70 | Â | +63 | |
Conserved hypothetical protein | PAAG_00520.1 | 1e-7 | Â | +1 | |
Hypothetical protein | PAAG_07199.1 | 7e-126 | Â | +7 | |
Hypothetical protein | PAAG_03580.1 | 0.0 | +6 | Â | |
Hypothetical protein | PAAG_04733.1 | 0.0 | +3 | Â | |
Hypothetical protein | PAAG_06820.1 | 0.0 | +1 | Â | |
Hypothetical protein | PAAG_08066.1 | 7e-71 | Â | +27 | |
Hypothetical protein | PAAG_05558.1 | 7e-76 | Â | +1 | |
Hypothetical protein | PAAG_03580.1 | 0.0 | Â | -1 | |
Hypothetical protein | PAAG_03099.1 | 2e-151 | Â | +45 | |
Hypothetical protein | PAAG_06251.1 | 0.0 | -3 | Â | |
Hypothetical protein | PAAG_01169.1 | 0.0 | +1 | Â | |
Hypothetical protein | PAAG_08809.1 | 0.0 | Â | +1 | |