|
E.coli0157:H-
|
|---|
|
MIC (μg/ml)
|
|---|
|
Lacticin 3147
|
Polymyxin B
|
Polymyxin E
|
Lacticin 3147/
|
FIC
|
Lacticin 3147/
|
FIC
|
|
Polymyxin B
|
Polymyxin E
|
|
231 (37.5 μM)
|
0.0586
|
0.0781
|
28.875/0.0073
|
0.250a
|
28.875/ 0.0049
|
0.188a
|
|
(α :124.74, Β: 106.26)
| | |
28.875 / 0.0147*
|
0.376*a
|
14.4375 / 0.0195*
|
0.312*a
|
|
Ltnα
|
Polymyxin B
|
Polymyxin E
|
Ltnα/
|
FIC
|
Ltnα/
|
FIC
|
|
Polymyxin B
|
Polymyxin E
|
|
187.11 (56.25 μM)
|
0.0586
|
0.0781
|
93.555 / 0.0073
|
0.625b
|
46.7775/ 0.0195
|
0.500a
|
|
(1.5 X Ltnα)
| | |
(6.0 X Ltnα in combin.)
| |
(6.0 X Ltnα in combin.)
| |
|
Ltnβ
|
Polymyxin B
|
Polymyxin E
|
Ltnβ/
|
FIC
|
Ltnβ/
|
FIC
|
|
Polymyxin B
|
Polymyxin E
|
|
495.88 (175 μM)
|
0.0586
|
0.0781
|
61.9850 / 0.0147
|
0.376a
|
30.9925 / 0.0195
|
0.313a
|
|
(4.7 X Ltnβ)
| | |
(4.7 X Ltnβ in combin.)
| |
(4.7 X Ltnβ in combin.)
| |
- FIC figures have been calculated as a result of triplicate experiments and indicate asynergy and bpartial synergy effects.*Alternative MIC and FIC data that allow for fixed levels of polymyxin across antimicrobial combinations, thus allowing for the calculation of the involvement of Ltnα and Ltnβ in synergy with polymyxin.
