Skip to main content

Table 3 IC 50 values (μM) of the naphthoquinones on intracellular amastigotes of T. cruzi

From: Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues

Cpd HMC Macrophages
NQ1 2.81 ± 0.43a,b 3.65 ± 0.71
NQ8 1.53 ± 0.11 1.49 ± 0.01
NQ9 2.48 ± 0.39 1.63 ± 0.18
NQ12 9.83 ± 2.64 2.51 ± 0.71
  1. aThe IC50 was calculated for the endocytic index (number of parasites/100 host cells) after two days of treatment.
  2. bMean ± standard deviation of at least three independent experiments.