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Table 3 Window of antiviral effects from CHLA and PUG against different viruses

From: Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry

Virus Treatments Window of antiviral effectsa
Free particle Attachment Penetration Post-infection Cell-to-cell spread
Method 1 Method 2b
HCMV CHLA +++ ++ +++ ++ +++ +++
PUG +++ ++ ++ ++ +++ +++
Heparin + ++ +++ + - -
HCV CHLA +++ +++ +++ +++ +++ +++
PUG +++ +++ +++ +++ +++ +++
Heparin ++ + +++ - + -
DENV-2 CHLA +++ +++ +++ +++ - -
PUG +++ +++ +++ +++ - -
Heparin ++ +++ +++ ++ - -
MV CHLA ++ ++ ++ ++ +++ +++
PUG ++ +++ ++ +++ +++ +++
Heparin ++ +++ ++ + - -
RSV CHLA +++ +++ +++ ++ - -
PUG +++ +++ +++ +++ - -
Heparin + +++ ++ ++ - -
  1. a Inhibitory effect (%) relative to DMSO control: +++ > 75%; ++ 50–75%; + 25–50%; - < 25%. Heparin was included for comparison.
  2. b Results from the highest inhibitory concentration of the compounds were used.