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Table 1 Antimicrobial susceptibility of MDR A. baumannii DB, R2 and pump deletion mutants

From: A Method for generating marker-less gene deletions in multidrug-resistant Acinetobacter baumannii

Antibiotic DB DB∆adeFGH DB∆adeIJK DB∆adeFGHadeIJK R2 R2∆adeFGH R2∆adeIJK R2∆adeFGHadeIJK
Nalidixic acid 512 512 128 128 1024 1024 256 256
Ciprofloxacin 64 64 64 64 128 128 128 128
Chloramphenicol 64 64 16 16 128 128 32 32
Tetracycline 512 512 128 128 512 512 128 128
Minocycline 2 2 0.25 0.25 2 2 0.5 0.5
Tigecycline 1 1 0.25 0.25 1 1 0.25 0.25
Meropenem 128 128 128 128 64 64 64 64
Imipenem 32 32 32 32 64 64 64 64
Piperacillin 512 512 512 512 256 256 256 256
Oxacillin > 1024 >1024 > 1024 >1024 1024 1024 1024 1024
Ceftazidime 256 128 256 256 256 128 512 512
Erythromycin 512 512 512 512 512 512 512 512
Clindamycin 128 128 16 16 128 128 16 16
Trimethoprim 128 128 16 16 128 128 16 16
Gentamicin >1024 >1024 >1024 >1024 >1024 >1024 >1024 >1024
Kanamycin >1024 >1024 >1024 >1024 >1024 >1024 >1024 >1024
  1. MIC (mg/L).
  2. Changes in MIC that are ≥ 4-fold are highlighted in bold.