Virulence factors | Genes related | Putative function | References |
---|---|---|---|
Pneumcoccal cell surface adherence protein A | pavA | Fibronectin binding | [26] |
Laminin-binding protein | lmb | Colonization | [22] |
Pilus-associated adhesin | rrgA | Colonization | [18] |
Sortase A | srtA | Adhesion to epithelial cells | [27] |
Streptococcal lipoprotein rotamase A | slrA | Colonization | [28] |
Streptococcal enolase | eno | Plasminogen binding | [29] |
Pneumococcal surface antigen | psaA | Adhesin | [30] |
C3-degrading protease | cppA | Evasion of innate immunity | [31] |
Serine protease | htrA/degP | Biogenesis of Streptolysin S | [14] |
Trigger factor | tig/ropA | Stress tolerance and biofilm formation | [32] |