Figure 4
From: Moraxella catarrhalis uses a twin-arginine translocation system to secrete the β-lactamase BRO-2
Features of the M. catarrhalis BRO-2 signal sequence. The M. catarrhalis ATCC43617 bro-2 gene product was analyzed using the SignalP 4.0 server. Panel A: The first 30 amino acid of BRO-2 are shown. Residues 1–26 specify characteristics of a prokaryotic signal sequence, specifically neutral (n, highlighted in yellow), hydrophobic (h, highlighted in blue) and charged (c, highlighted in red) regions. The highly-conserved twin-arginine recognition motif is bolded and underlined. Panel B: Features of a typical TAT signal sequence where x represents any amino acid (adapted from [59]). The arrowheads indicate signal peptidase cleavage sites.