Pathways along which Wolbachia may affect egg chamber formation in region 2a/2b of the germarium. A, localization of regions in the germarium (framed) where the bacteria may interfere with normal function of cells. B, the bacteria disturb the differentiation of cystocytes (white) into the oocyte (light orange) and the nurse cells (light violet). C, the bacteria skew the proper ratio of germline cells to follicle cells. Crescent shape, SSCN; green circle, SSC; green ovals, follicle cells. Red points represent the bacteria.