Table 2 Determination of minimal inhibitory concentrations (MICs) of potential low-level resistant strains (to RIF, SM, PZA)
strain | mutation | RIF MIC [μg/ml] |
|---|---|---|
4518/03 | rpoB Asp516Tyr (gac/tac) | 0.5 |
5472/03 | rpoB Leu533Pro (ctg/ccg) | 1.0 |
10011/03 | rpoB Asp516Tyr (gac/tac) | 0.5 |
3736/04 | rpoB Leu511Pro (ctg/ccg) | 0.5 |
6467/04 | rpoB Asp516Tyr (gac/tac) | 0.25 |
H37Rv control | wild type | 0.25 |
strain | mutation | SM MIC [μg/ml] |
6463/04 | rpsL Lys88Arg (aag/agg) | 0.5 |
H37Rv control | wild type | 0.5 |
strain | mutation | PZA MIC [μg/ml] |
4724/03 | pncA Thr47Ala (acc/gcc) | 25.0 |
4730/03 | pncA Thr47Ala (acc/gcc) | 25.0 |
6467/04 | pncA Lys96Glu (aag/gag) | 12.5 |
H37Rv control | wild type | 12.5 |