Figure 5From: FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis(A) Time course for FK506 production in the SPM2 medium. (B) Gene expression analysis by RT-PCR. Results of transcript analysis from three strains are presented WT-wild type, ΔR-fkbR inactivated, ΔN-fkbN inactivated. Total mycelial RNA was extracted after 36, 72 and 103 hours of fermentation.Back to article page