Table 3 Approximate percentages of organisms showing ultrastructural alterations observed in two H. pylori strains after treatment with polysorbate 80, clarithromycin, metronidazole, polysorbate 80/clarithromycin and polysorbate 80/metronidazole
From: Polysorbate 80 and Helicobacter pylori: a microbiological and ultrastructural study
Parameters | Controls | Polysorbate 80 | Clarithromycin | Metronidazole | Polysorbate 80/ | Polysorbate 80/ | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Clarithromycin | Metronidazole | |||||||||||
CCUG 17874 | C/M-R2 | CCUG 17874 | C/M-R2 | CCUG 17874 | C/M-R2 | CCUG 17874 | C/M-R2 | CCUG 17874 | C/M-R2 | CCUG 17874 | C/M-R2 | |
% Altered Shape | 5 | 3 | 90 | 60 | 85 | 50 | 85 | 5 | 100 | 95 | 85 | 80 |
% Granular Cytoplasm | 1 | 3 | 90 | 70 | 10 | 40 | 5 | 5 | 75 | 60 | 70 | 65 |
% Altered outer membrane | 1 | 1 | 75 | 75 | 20 | 35 | 20 | 1 | 70 | 75 | 70 | 75 |
% Presence of “holes” in the cytoplasm | 0 | 0 | 1 | 0 | 40 | 2 | 2 | 1 | 20 | 1 | 1 | 15 |
% Detachment membrane/cytoplasm | 3 | 1 | 10 | 2 | 30 | 2 | 60 | 2 | 25 | 2 | 50 | 10 |
% Presence of flagella | YES | YES | NO | YES | YES | YES | NO | YES | YES | YES | NO | NO |
% Presence of vesicles | - | + | ++ | ++++ | - | ++ | - | + | +/− | ++++ | ++ | ++ |