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Table 2 Time series of macrolide resistance gene presence, sequence types, and serotypes in S. pneumoniae clinical isolates

From: Dominance of multidrug resistant CC271 clones in macrolide-resistant Streptococcus pneumoniae in Arizona

       Time period    
  1999-2000 2001-2002 2003-2004 2005-2006 2007-2008
Macrolide-resistant S. pneumoniae population Sequence types (no. isolates) Serotyp ea (no. tested) No. isolates Sequence types (no. isolates) Serotypea (no. tested) Sequence types (no. isolates) Serotypea (no. tested) Sequence types (no. isolates) Serotypea (no. tested)
Dual mef(E)/erm(B)-positive 271 (4) 19F (4) 0 320b (2) 19A (2) 320b (19) 19A (16) 320b (24) 19A (21)
  1412b,e (1) 19F (1)   1396b (2) 19F (2) 320b,e (2) 19A (1) 1459b (1) NT
  3039b,g (1) 19F (1)   271 (1) 19F (1) 271 (2) 19F (2) NFb (1) 19A (1)
  NFb,c (2) 19F (2)   NT (1) 19F (1) 1459b (2) 19F (1) NTe (1) NT
  NTd (1) 19F (1)     3039b (1) 19F (1)   
       1396b,e (1) 19F (1)   
       NFb (3) 19F (2)   
       NT (1)    
Total for time period 9 (39.1%)    6 (40.0%)   31 (58.5%)   27 (67.5%)  
mef(E)-positive 236b (2) 19F (2) 0 376 (2) 6A (2) 2705 (3) 33A/F/37 (3) 3280 (3) NT
  13g (1) NT   1186 (2) NT 1186 (3) NT 1379 (2) 6C (2)
  156 (1) 6A (1)   1556 (1) NT 236b (2) 19F (2) 162f (1) NT
  376 (1) 6A (1)   6422 (1) NT 156 (1) 9V (1) 199 (1) 19A (1)
  384f (1) 6B (1)   NTf (1) 6C 199 (1) 19A (1) 344 (1) NT
  384g (1) 6B (1)     558 (1) 35B (1) 1518 (1) 6B (1)
  NFg (1) NT     1379 (1) 6C (1) NF (1) 6A (1)
  NT (2) NT     3065 (1) 6C (1)   
  NTf (1) NT     NFf (1) 19F (1)   
       NT (1) 6C (1)   
       NTf (1) NT   
Total for time period 11 (47.8%)    7 (46.7%)   16 (30.2%)   10 (25.0%)  
erm(B)-positive 315 (2) 6B (2) 0 63 (1) 15A/15F (1) 63 (5) 15A/15F (5) 63 (2) 15A/15F (2)
  3066g (1) 18A/B/C/F (1)   NT (1)   180 (1) 3 (1)   
Total for time period 3 (13.1%)    2 (13.3%)   6 (11.3%)   2 (5.0%)  
mef(A)-positive         1111 (1) 6C (1)
Total for time 0   0 0   0   1 (2.5%)  
Total macrolide resistant/Total no. isolates collected 23/131 (17.6%) 0/34 (0%) 15/54 (27.8%) 53/223 (23.8%) 40/150 (26.7%)     
  1. a Serotype deduced by PCR; serotypes in bold are non-vaccine types
  2. b Sequence type is a single locus variant of ST271
  3. c NF, Sequence type not found in MLST database
  4. d NT, Not typed
  5. e Dual-positive with M-phenotype (n = 5)
  6. f mef(E)-positive with MLSB phenotype (n = 6)
  7. g Invasive isolate (n = 5)