Fusidic acid resistance among clinical isolates of methicillin-resistant Staphylococcus aureus in a Taiwanese hospital

Table 1 Characteristics and mechanisms of the 34 fusidic acid-resistant MRSA clinical isolates

Isolate	Specimen	FA MIC (μg/ml)	VAN MIC (μg/ml)	LZD MIC (μg/ml)	OXA MIC (μg/ml)	RIF MIC (μg/ml)	*fusC*	*Polymorphism(s)* inEF-G	PFGE patterns
1	Pus	8	1	1	>2	< = 0.5	-	H₄₅₇Y	A1
2	Pus	32	1	2	>2	< = 0.5	+	-	A1
3	Pus	8	1	1	>2	< = 0.5	+	-	A1
4	Sputum	16	1	2	>2	< = 0.5	+	H₄₅₇Y	A1
5	Sputum	32	2	2	>2	>2	+	-	A1
6	Pus	16	1	1	>2	>2	+	-	A2
7	Pus	8	1	1	>2	< = 0.5	+	-	A3
8	Sputum	16	1	1	>2	< = 0.5	+	-	A3
9	Pus	16	1	1	>2	< = 0.5	-	G₅₅₆S	A3
10	Sputum	16	1	1	>2	< = 0.5	-	H₄₅₇Y, G₅₅₆S	A3
11	Ascites	8	1	1	>2	< = 0.5	-	H₄₅₇Y	A3
12	Pus	64	2	2	>2	< = 0.5	+	-	A3
13	Sputum	64	2	2	>2	< = 0.5	-	H₄₅₇Y	A3
14	Pus	16	1	1	>2	< = 0.5	+	-	A3
15	Blood	4	1	1	>2	< = 0.5	+	-	A3
16	Pus	8	1	1	>2	< = 0.5	+	-	A3
17	Blood	8	1	1	>2	< = 0.5	+	-	A3
18	Blood	16	1	1	>2	< = 0.5	+	-	A3
19	Blood	16	1	1	>2	< = 0.5	+	-	A3
20	Pus	2	2	1	>2	< = 0.5	+	-	A3
21	Urine	2	2	2	>2	< = 0.5	-	H457Y, G556S	A3
22	Sputum	2	2	2	>2	< = 0.5	+	-	A3
23	Pus	16	2	1	>2	>2	-	H457Y	A4
24	Pus	2	1	1	>2	< = 0.5	+	-	A5
25	Urine	16	1	1	>2	< = 0.5	+	-	A6
26	CVP tip	8	1	2	>2	< = 0.5	+	-	A6
27	Pus	2	2	2	>2	< = 0.5	+	-	A6
28	Sputum	16	1	2	>2	< = 0.5	+	-	A7
29^a	Pus	8	1	2	>2	< = 0.5	+	-	A8
30	Sputum	16	1	2	>2	< = 0.5	+	-	A9
31	Pus	16	1	2	>2	< = 0.5	-	H457Y, R659L	A9
32	Sputum	8	1	2	>2	< = 0.5	+	-	A9
33	Blood	16	1	1	>2	< = 0.5	-	G556S	A9
34	Pus	2	2	2	>2	< = 0.5	+	-	A9

FA, fusidic acid; VAN, vancomycin; LZD, linezolid; OXA, oxacillin; RIF, rifampin
^a nonsense mutation in fusC (S175 was encoded by TAA rather than TCA)

ISSN: 1471-2180